
Anionic salts are added to the diets of dairy cows and sheep to prevent milk fever and increase plasma calcium levels. The effects of anionic salts on calcium absorption have been studied in cows and sheep, with conflicting results. While anionic salts have been shown to increase plasma calcium levels, they may also negatively impact dry matter intake and energy balance. The impact of anionic salts on calcium absorption and metabolism is influenced by factors such as the dietary cation-anion difference (DCAD) and the specific type of anionic salt used. This raises the question: do anionic salts change the crude protein of a diet?
Do anionic salts change the crude protein of a diet?
| Characteristics | Values |
|---|---|
| Effect on calcium absorption | Increased plasma calcium levels |
| Effect on fermentation | No effect on fermentation products |
| Effect on mineral concentrations | Increased ruminal concentrations of Cl, Mg, and Ca |
| Effect on blood pH | Lowered urine pH |
| Effect on energy balance | Negative effect on energy balance |
| Effect on body weight | Reduced body weight loss |
| Effect on insulin levels | Lower insulin levels |
| Effect on protein content | May not properly adjust for existing protein content |
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What You'll Learn
- Anionic salts are added to prepartum diets to prevent milk fever in cows
- Anionic salts increase plasma calcium levels in female goats
- Anionic salts can be used to treat sheep with calcium absorption issues
- Anionic salts are used to treat cows with calcium metabolism issues
- Anionic salts can be used to treat cows with low blood calcium levels

Anionic salts are added to prepartum diets to prevent milk fever in cows
The principle behind feeding anionic salts is to acidify the dry cow diet to modify the electrical charge of the blood. In doing so, the parathyroid hormone (PTH) receptors can function properly, allowing the cow to mobilize calcium from the bone to meet the demands of lactation. The most common cations found in feed are sodium, potassium, calcium, and magnesium, while the most common anions are chloride, sulfate, and phosphate.
The success of a dietary cation-anion difference (DCAD) program can be evaluated by monitoring the urinary pH of the cow. If the urine fails to be acidified, the inclusion rate of anionic salts in the diet may need to be adjusted. The level of anionic salts necessary to sufficiently acidify the diet is determined by the DCAD of the dry cow diet.
Anionic salts are typically added to the diet in the form of chloride and sulfate salts. Chloride salts have been found to be more potent systemic acidifiers than sulfate salts, but they also depress dry matter intake to a greater extent. Examples of chloride anionic salts include MgCl2, CaCl2, and NH4Cl, while examples of sulfate anionic salts include MgSO4, CaSO4, and (NH4)2SO4.
The addition of anionic salts to prepartum diets has been shown to effectively prevent milk fever in cows by reducing the incidence of clinical and subclinical hypocalcemia.
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Anionic salts increase plasma calcium levels in female goats
Anionic salts are added to the diets of dairy cows and female goats to prevent milk fever, a condition caused by a decline in blood calcium concentrations during lactation. This condition can be prevented by reducing the dietary cation-anion difference (DCAD) to negative values, which minimises the rapid decline in blood calcium.
In a study by Yang et al. (2021), female goats were fed a negative DCAD diet to determine the effects on their rumen fermentation, rumen microbial population, and plasma calcium levels. The results indicated that feeding a negative DCAD had no harmful effects on rumen fermentation and rumen microbial population. Additionally, the female goats exhibited increased plasma calcium levels.
The study also found that the level of feed intake is crucial for animal growth performance. Pure anionic salt can reduce feed intake due to its bitter taste and poor palatability. However, this issue can be mitigated by mixing the anionic salts with molasses and dried distillers' grains with solubles, as observed in a previous study by Takagi and Block.
In another study by Gelfert et al. (2007), the impact of DCAD on calcium metabolism and acid-base balance in non-lactating, non-pregnant dairy cows was investigated. The results demonstrated that anionic salts can stimulate calcium absorption from the rumen, leading to increased plasma calcium levels.
Overall, the use of anionic salts in the diets of female goats has been shown to increase plasma calcium levels without causing any detrimental effects on rumen fermentation or rumen microbial population. However, it is important to consider the palatability of anionic salts to ensure adequate feed intake for optimal growth performance.
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Anionic salts can be used to treat sheep with calcium absorption issues
The use of anionic salts to treat calcium absorption issues in sheep is part of a broader understanding of the dietary cation-anion difference (DCAD) and its impact on calcium metabolism. DCAD is a concept that relates to the balance of positively and negatively charged ions in an animal's diet. By manipulating the DCAD, it is possible to influence the acid-base balance in the body, which in turn affects calcium absorption.
In one study, sheep were fed diets that were either positive or negative in DCAD for three weeks. The results showed that a negative DCAD diet induced a compensated hyperchloremic metabolic acidosis, which increased plasma chloride and ionised calcium concentrations. This indicates that anionic salts can stimulate calcium absorption in the rumen, independent of vitamin D.
Anionic salts can also be used to prevent parturient paresis, a condition related to low blood calcium levels during the onset of lactation. By reducing the DCAD to negative values in the weeks leading up to parturition, the rapid decline in blood calcium can be minimised. This strategy has been successfully employed in dairy cows, and similar principles may apply to sheep.
It is important to note that the effectiveness of anionic salts in treating calcium absorption issues may depend on the specific mineral and protein content of the diet. A proper analysis of available forages and the formulation of a specific concentrate and mineral mixture is recommended to create the desired final diet. Additionally, the palatability of anionic mineral salts has been a concern in some studies, which may impact their practical use.
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Anionic salts are used to treat cows with calcium metabolism issues
Feeding cows anionic salts in late gestation is a widely used method to prevent milk fever. Anionic salts reduce the rapid decline in blood calcium by minimising the reduction in dietary cation-anion difference (DCAD) to negative values during the last three weeks prepartum. This is achieved by reducing DCAD to between -50 and -150 mEq/kg of DM.
The impact of dietary cation-anion difference (DCAD) on the acid-base balance and calcium metabolism of non-lactating, non-pregnant dairy cows has been studied. The results show that anionic salts increase plasma calcium levels and induce a mild, compensated metabolic acidosis, evidenced by decreased blood bicarbonate concentrations and decreased blood base excess.
Anionic salts can be administered in standard doses or by systematic calculation of mineral content and DCAD. Standard doses may not properly adjust for the existing mineral and protein content of the prepartum diet, so a better approach is to analyse available forages and formulate a specific concentrate and mineral mixture to create the desired final diet.
It is important to note that overdosing anionic salts may induce a more severe metabolic acidosis, which has proven not to be advantageous to dairy cows. Metabolic acidosis can be monitored through urine pH, which should be maintained between 6.0 and 6.8 to prevent milk fever.
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Anionic salts can be used to treat cows with low blood calcium levels
Anionic salts are used to treat milk fever in cows, a condition caused by low blood calcium levels. This is achieved by reducing the dietary cation-anion difference (DCAD) to negative values during the last 3 weeks prepartum. The reduction in DCAD minimises the rapid decline in blood calcium concentrations that occurs at the onset of lactation.
The use of anionic salts during the pre-fresh period has been shown to decrease the incidence of hypocalcemia in dairy herds. Hypocalcemia, or low blood calcium, can have significant negative effects on both animal health and the profitability of dairy farms. As there are rarely clinical signs of subclinical hypocalcemia, it is often undiagnosed in commercial farms.
Anionic salts are added to prepartum diets to further decrease blood pH and improve calcium metabolism. This supports the cow's elevated calcium demands for colostrum and milk production around calving. The use of low-potassium diets in association with mineral anionic supplements has been shown to be effective.
Standard doses of anionic salts include 114 g MgSO4·7H2O plus 114 g NH4Cl (3.0 equivalents of anions). However, this strategy may not properly adjust for the existing mineral and protein content of the prepartum diet. A better approach is to analyse available forages and formulate a specific concentrate and mineral mixture to create the desired final diet.
Research has shown that anionic salt treatments do not decrease dietary DM intake compared to a control diet without salts. While blood pH is not affected by the salt treatments, mild metabolic acidosis is evidenced by decreased blood bicarbonate concentrations and decreased blood base excess. Urinary pH and base excess are also lowered, and fractional excretion of urinary Ca is increased.
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Frequently asked questions
Anionic salts are salts with a negative charge, such as chloride and sulfate salts.
Anionic salts can affect the body in various ways, including altering blood pH, mineral status, and energy metabolism. They can also influence reproduction and production in dairy cows.
Anionic salts can affect protein content in diets. For example, in cows, feeding diets excessive in crude protein with high rumen degradability should be avoided.
Anionic salts help prevent milk fever by reducing the rapid decline in blood calcium (Ca) concentrations during the onset of lactation.
Yes, the palatability of anionic mineral salts has been a concern. Additionally, some anionic salts, like chlorides, can depress dry matter intake.











































