The keto diet is a high-fat, low-carbohydrate diet that has been used to treat epilepsy since the 1920s. It has gained popularity in recent years as a weight loss method and is also being studied for its potential to treat other conditions such as Alzheimer's, Parkinson's, and cancer.
The keto diet works by changing the way the body burns energy. On a typical Western diet, most of the body's energy comes from carbohydrates, which cause the body to produce insulin. On a keto diet, where carbs are extremely limited, the body instead draws its energy from dietary fat and the body's fat storage, which produces ketone bodies.
The keto diet is considered safe but it is very strict and can be hard to follow. It is also more expensive than a typical American diet. There is some evidence that it can help with weight loss and improve blood sugar control for patients with type 2 diabetes, but there is no long-term research on its effects.
Characteristics | Values |
---|---|
--- | --- |
Diet type | High-fat, adequate-protein, very-low-carbohydrate |
History | Used to treat epilepsy since the 1920s |
Mechanism | Mimics the metabolism of the fasting state to induce the production of ketone bodies |
Evidence | Effective in treating epilepsy, obesity, type 2 diabetes, cancer, intestinal disorders, respiratory compromise, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, depression, anxiety, and COVID-19 |
Side effects | Fatigue, irritability, headache, nausea, dehydration, hypoglycaemia, diarrhoea, metabolic acidosis, refusal to eat, elevated cardiovascular risks, and nephrolithiasis |
What You'll Learn
The ketogenic diet can be used to treat epilepsy
The ketogenic diet has been used to treat epilepsy since the 1920s. It is a high-fat, low-carbohydrate diet that has been proven to reduce seizures in many patients. The diet works by changing how the brain gets energy to function. Instead of the body using carbohydrates for energy, the ketogenic diet teaches the body to burn fat for energy instead. This is called ketosis.
The ketogenic diet is usually recommended for children with epilepsy that continues despite medication. It is not usually recommended for adults because the restricted food choices make it hard to follow. However, the modified Atkins diet does work well for adults. The diet is carefully monitored by a dietitian and a neurologist, and the patient is usually admitted to the hospital when the diet begins.
Several studies have shown that the ketogenic diet does reduce or prevent seizures in many children whose seizures could not be controlled by medications. Over half of children who go on the diet have at least a 50% reduction in the number of their seizures. Some children, usually 10-15%, even become seizure-free.
The ketogenic diet can be adapted to different cultures and for people with allergies or those on modified texture diets. The dietitian calculates the diet and tries to include foods that the patient likes. The diet can be used in children and adults of any age, although infants need close monitoring.
The ketogenic diet is not recommended as a primary anti-seizure option because patients are often averse to drastic changes in their food intake or have trouble staying on the diet due to its strict requirements and potential side effects like nausea, constipation, and fatigue. However, for those who do not respond to existing anti-seizure medications, the ketogenic diet can be a beneficial treatment for epilepsy.
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The ketogenic diet can be used to treat obesity
Ketogenic diets have been shown to be effective in the short to medium term as a tool to fight obesity. They are very-low-carbohydrate diets, with fat comprising >70% of calories. They have been shown to be more effective than low-fat diets for the treatment of obesity and diabetes. In addition to the reductions in blood glucose and insulin achievable through carbohydrate restriction, chronic ketosis might confer unique metabolic benefits relevant to cancer, neurodegenerative conditions, and other diseases associated with insulin resistance.
A 2004 study found that a 24-week ketogenic diet significantly reduced the body weight and body mass index of obese patients. Furthermore, it decreased the level of triglycerides, LDL cholesterol, and blood glucose and increased the level of HDL cholesterol. Administering a ketogenic diet for a relatively longer period of time did not produce any significant side effects in the patients.
Ketogenic diets have also been shown to be effective in the treatment of epilepsy. They are recommended as a nonpharmacological treatment for medication-refractory epilepsy in children and adults and have been shown to reduce seizure frequency in patients.
However, there are some concerns about the use of ketogenic diets as therapeutic tools. One concern regards blood lipids. Ketogenic diets have been reported to increase the size and volume of LDL-C particles, which is considered to reduce cardiovascular disease risk. However, there is also evidence that ketogenic diets are associated with a clinically meaningful increase in LDL-C.
Another concern is the effect of ketogenic diets on bone health. Short-term ketogenic diets have been shown to impair bone mass density and mechanical properties of bone in mice, and very long-term ketogenic diets in children with intractable epilepsy may lead to a progressive reduction of bone mineral content. However, the majority of studies on the effects of dietary protein levels on bone metabolism in humans have been performed on epileptic children, and recently published articles have suggested that there is not a negative effect on bone health.
Overall, the ketogenic diet can be a useful tool to treat obesity in the hands of a physician.
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The ketogenic diet can be used to treat type 2 diabetes
The ketogenic diet was originally created in the 1920s as a treatment for epilepsy. On the keto diet, the body converts fat, instead of sugar, into energy. The body achieves a state of ketosis, where it uses ketones to create energy, instead of glucose. This can lead to rapid weight loss, which is beneficial for people with type 2 diabetes, as many are overweight.
The keto diet can be effective in managing type 2 diabetes by lowering blood sugar and promoting weight loss. Research has shown that the keto diet can lead to more significant improvements in blood sugar control, A1C, weight loss, and discontinued insulin requirements than other diets.
However, the keto diet may not be suitable for everyone with type 2 diabetes. The diet is restrictive and can be difficult to stick to in the long term. It may also lead to low blood sugar, or hypoglycaemia, which can be dangerous. It is important for people with type 2 diabetes to monitor their blood sugar levels regularly and speak with their doctor before making any dietary changes.
The keto diet may also not provide adequate nutrients and can be low in fibre, leading to constipation. It is important to eat a balanced diet that includes heart-healthy fats, fruits, vegetables, whole grains, beans, nuts and moderate amounts of lean poultry, fish and dairy.
Overall, the ketogenic diet can be a safe and effective way to treat type 2 diabetes, but it is important to consult with a doctor or dietitian to determine if it is the right approach for an individual's specific needs and goals.
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The ketogenic diet can be used to treat nonalcoholic fatty liver disease
The ketogenic diet can reduce insulin levels and insulin resistance, which are key factors in the development of NAFLD. The ketogenic diet can also reverse the disease process by reducing liver fat, inflammation, and fibrosis. The ketogenic diet has been shown to suppress appetite, promote abdominal fat loss, and improve heart health markers.
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The ketogenic diet can be used to treat polycystic ovarian syndrome
Preliminary data suggests that the very low-calorie ketogenic diet (VLCKD) improves body weight and composition, metabolic profile (glucose, serum insulin, triglycerides, total and low-density lipoprotein cholesterol), and insulin resistance following VLCKD. However, the evidence is still scarce and needs to be more substantiated.
Weight reduction in women with PCOS has been shown to improve metabolic derangements and body composition, but there is no consensus on the ideal dietary pattern or macronutrient composition. There is some evidence supporting the possible role of the Mediterranean diet in improving infertility (along with other well-known metabolic benefits) in women with PCOS. Of note, VLCKD might be considered a potential intervention for the short-term treatment of PCOS, but it must be prescribed and carefully guided by professionals.
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Frequently asked questions
The keto diet is a high-fat, low-carbohydrate diet that causes the body to release ketones into the bloodstream. The body's main source of energy is usually derived from carbohydrates, but when these are extremely limited, the body instead draws its energy from dietary fat and the body's fat storage, which produces ketone bodies.
The keto diet has been shown to reduce seizures in children with epilepsy, and there is some evidence that it can aid weight loss and improve blood sugar control for patients with type 2 diabetes.
The keto diet is hard to follow, and it can be heavy on red meat and other fatty, processed, and salty foods that are notoriously unhealthy. It may also cause side effects such as bad breath, nausea, vomiting, constipation, and sleep problems. It is also more expensive than a typical American diet.