
Poor diet is a leading cause of death globally, with 11 million deaths attributed to poor nutrition. A diet high in saturated fat, cholesterol, salt, and sugar can cause severe damage to the arteries, leading to life-threatening cardiovascular diseases. This is because foods high in saturated fat and cholesterol cause plaque build-up in the arteries, a condition known as atherosclerosis. This build-up can restrict blood flow, increasing the risk of heart disease and other severe complications. However, diet and lifestyle changes can help prevent and manage these conditions.
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What You'll Learn

High cholesterol levels
Cholesterol plaques, also known as atherosclerosis, form when there is a high level of low-density lipoprotein (LDL) or "bad" cholesterol in the blood. These plaques cause damage to the arteries by building up on their inner walls, leading to a process called "hardening of the arteries" or arteriosclerosis. Over time, the plaques grow silently and slowly, narrowing the arteries and restricting blood flow. This can result in chest pain during physical activity and, if left untreated, can lead to more severe complications such as heart attacks and strokes.
LDL cholesterol is considered "bad" because it contributes to plaque formation and can damage arteries. On the other hand, high-density lipoprotein (HDL), or "good" cholesterol, helps protect arteries by transporting excess cholesterol back to the liver from the body's organs and tissues. A healthy balance between LDL and HDL cholesterol is crucial for maintaining artery health.
Diet plays a significant role in managing cholesterol levels. Foods high in saturated fat, such as red meat, eggs, and dairy products, can increase the build-up of plaques in the arteries. Therefore, it is recommended to consume a diet low in cholesterol and saturated fat. Soluble fibre, found in foods like nuts, can help lower LDL cholesterol. Oily fish and other foods rich in omega-3 fatty acids are also beneficial for increasing HDL cholesterol levels.
In addition to diet, regular exercise can help improve cholesterol levels and reduce the risk of cardiovascular complications. Certain medications, such as statins, can also be prescribed to lower LDL cholesterol levels and improve overall heart health. Maintaining healthy cholesterol levels is essential for preventing artery damage and reducing the risk of associated medical conditions.
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High saturated fat intake
Saturated fats are one of the unhealthy fats, along with trans fats. They are most often solid at room temperature and are found in butter, palm and coconut oils, cheese, and red meat. A high intake of saturated fats can lead to raised levels of LDL cholesterol, which is known as "bad" cholesterol because it can build up inside your arteries, causing them to become narrowed. This increases your risk of heart disease and stroke.
A study published in August 2021 in the journal Science found that a high intake of saturated fat increases the number of metabolites that build plaques in the arteries. The study showed that a high-fat diet disrupts the bacterial balance in the gut, leading to the production of harmful substances implicated in cardiovascular diseases. Specifically, it was found that a high-fat diet causes an imbalance in the microbiota, favouring harmful microbes. When the bacteria in the gut break down food containing choline, a nutrient found in red meat, eggs, and dairy products, they produce a metabolite known as trimethylamine (TMA). TMA is then oxidized and converted in the liver into TMAO (trimethylamine-N-oxide). People with higher levels of TMAO in their blood have more than twice the risk of serious heart problems.
To reduce your intake of saturated fats, it is recommended to replace foods high in saturated fats with healthier options containing unsaturated fats such as canola, soybean, and olive oil. The American Heart Association recommends aiming for a dietary pattern that achieves less than 6% of total calories from saturated fat. For a 2,000-calorie diet, this equates to no more than 120 calories or 13 grams of saturated fat per day. It is also suggested to eat more fruits, vegetables, whole grains, and other foods with low or no saturated fat.
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Low vegetable and fruit consumption
A diet low in vegetables and fruits can cause damage to the arteries in several ways. Firstly, it can lead to an increased risk of coronary heart disease. Research has shown that each one-serving-per-day increase in fruit or vegetable intake is associated with a 4% lower risk of coronary heart disease. This is especially true for green leafy vegetables and vitamin C-rich fruits and vegetables, which appear to have a protective effect against this disease.
Secondly, a diet low in vegetables and fruits can contribute to high cholesterol levels, specifically high LDL (low-density lipoprotein) cholesterol levels, also known as "bad" cholesterol. This type of cholesterol can build up inside the arteries, causing them to become narrowed and increasing the risk of atherosclerosis, a condition characterized by the thickening of the arteries due to fatty deposits. Atherosclerosis is a major underlying cause of heart disease, including coronary artery disease.
Additionally, a diet lacking in vegetables and fruits can lead to increased inflammation in the body. Certain vegetables, such as onions from the Allium genus, contain sulfur compounds that help prevent blood vessel inflammation. A diet rich in cruciferous vegetables like broccoli, cabbage, and cauliflower has also been linked to a decreased risk of atherosclerosis and improved artery health.
Furthermore, low vegetable and fruit consumption can impact weight management. Fruits and vegetables are high in dietary fibre, which promotes satiety and reduces hunger, helping to prevent unhealthy weight gain. Being overweight or obese is a risk factor for coronary artery disease and can contribute to high cholesterol levels, further damaging the arteries.
Finally, a diet low in vegetables and fruits can be deficient in specific nutrients that support artery health. For example, beets are a good source of nitrates, which the body converts to nitric oxide, a signalling molecule that plays essential roles in maintaining healthy blood vessels and reducing inflammation.
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High red meat consumption
Plaque build-up, or atherosclerosis, occurs when there is a build-up of fatty deposits inside the arteries, causing them to narrow and increasing the risk of serious heart problems. A nutrient called choline, commonly found in red meat, is broken down by bacteria in the gut to produce a metabolite called trimethylamine (TMA). TMA is then converted in the liver into trimethylamine N-oxide (TMAO). High levels of TMAO in the blood have been associated with a more than doubled risk of heart disease and plaque deposits in the arteries.
Research has shown that a diet high in red meat can lead to elevated TMAO levels in the blood. A clinical trial involving 113 healthy participants found that those who consumed a diet of red meat equivalent to two quarter-pound beef patties per day had three times higher TMAO levels compared to those on diets based on white meat or non-meat protein sources. Importantly, the TMAO increases were reversible, with participants' TMAO levels decreasing significantly when they discontinued the red meat diet.
In addition to saturated fat, other constituents of red meat, such as heme iron, sodium, and preservatives, have been implicated in adverse cardiovascular effects. Processed red meats, in particular, have been associated with a higher risk of coronary heart disease and diabetes due to their content of preservatives that promote blood pressure elevation and vascular inflammatory processes.
It is worth noting that the impact of red meat consumption on cardiovascular health may vary among individuals, with those already at high risk for cardiovascular disease potentially being more vulnerable to the dietary effects of red meat.
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High egg consumption
High consumption of eggs has been a topic of debate in the nutrition world for a while now. On the one hand, eggs are a significant source of cholesterol, with an average of 213 mg per egg. Cholesterol, especially LDL or "bad" cholesterol, can build up inside arteries, causing them to narrow and increasing the risk of cardiovascular disease. This has led to dietary guidelines advising against the consumption of cholesterol-rich foods like eggs.
However, recent research has shown that most of the cholesterol in our bodies is made by our liver and is stimulated primarily by saturated fats and trans fats in our diet, rather than dietary cholesterol. Eggs contain a minimal amount of saturated fat (about 1.5 grams per large egg) and also provide many essential nutrients like lutein, zeaxanthin, choline, and vitamins A, B, and D.
Several studies, including those conducted at Harvard Medical School, have followed large groups of people over decades and found no increased risk of cardiovascular disease in those consuming up to one egg per day. In fact, egg consumption has been shown to increase HDL or "good" cholesterol, which protects arteries from plaque build-up. Additionally, the LDL-HDL ratio, a strong predictor of CVD risk, remains unaffected in humans consuming three eggs per day for a month.
While the evidence suggests that one egg per day is safe for most people, it is important to consider what you eat with your eggs. The saturated fat in foods like butter, cheese, bacon, and sausage can significantly raise your blood cholesterol levels. Therefore, while high egg consumption may not directly cause damage to the arteries, it is crucial to maintain a balanced diet and be mindful of the way eggs are prepared and consumed.
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Frequently asked questions
A diet high in saturated fat and choline, which is found in red meat, eggs, and dairy products, increases the number of metabolites that build plaques in the arteries. This can lead to atherosclerosis, a cardiovascular disease where fatty deposits build up inside the arteries.
Plaque buildup can reduce blood flow and cause severe complications. Over time, it can lead to thickened or hardened arteries, which can result in atherosclerosis and increase the risk of heart disease.
Yes, a diet rich in vegetables, fruits, whole grains, nuts, and healthy fats can help reduce the risk of clogged arteries. Cruciferous vegetables like broccoli, cabbage, and cauliflower are especially beneficial. Onions, which contain sulfur compounds, may also help prevent blood vessel inflammation and inhibit platelet clumping.
Yes, some dietary supplements such as bergamot, berberine, artichoke leaf extract, red yeast rice, and plant stanols/sterols may help lower LDL cholesterol levels and reduce the risk of cardiovascular disease. However, it is always best to consult a healthcare professional before taking any supplements.











































