
The OPTIFAST® weight loss program is a medically-supervised meal replacement program designed to help overweight and obese patients lose weight and improve their health. The program includes medical, nutritional, and behavioural support, with a focus on long-term lifestyle changes. OPTIFAST® products are clinically proven, nutritionally complete, and balanced, providing 100% of the recommended daily value of at least 24 vitamins and minerals. The program is designed to be safe and effective, with medical monitoring and support to help patients achieve sustainable weight loss and improve their overall health and emotional well-being.
| Characteristics | Values |
|---|---|
| Scientific basis | The Optifast® diet plans are clinically proven, nutritionally complete and balanced, and medically endorsed. |
| Nutritional value | Optifast® products are nutritionally complete and balanced, delivering between 160 and 230 kcal per serving and including 100% of the recommended daily value for at least 24 vitamins and minerals. |
| Medical supervision | The OPTIFAST® Program is a medically-supervised weight loss program that closely monitors and assesses progress towards better health and emotional well-being. |
| Safety | Clinical studies suggest medically-monitored, weight-management programs are safe, effective, and help individuals address and modify behaviors to encourage long-term weight management. |
| Effectiveness | The OPTIFAST® Program is a clinically proven, effective weight loss program. |
| Relapse | Patients often gain weight back after the program has been completed. Relapse is not unusual, but persistence is key. |
| Cost | The price per product is about $4 to $5 and is not covered by insurance, but may be covered by a flexible spending account. |
| Eligibility | OPTIFAST® is for people with a BMI of 30 or above or a BMI of 27 to 30 with weight-related conditions such as prediabetes, diabetes, high blood pressure, high cholesterol, sleep apnea, joint pain, or liver disease. |
| Duration | The OPTIFAST® Program is offered in 12- or 24-week programs. |
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What You'll Learn

Optifast's meal replacement products
Optifast is a clinically proven, nutritionally complete and balanced, and medically endorsed meal replacement program. It is designed to help people lose weight and improve their health through a comprehensive program that includes medical, nutritional, and behavioural support. The program is offered through the Duke Lifestyle and Weight Management Center and is conducted in collaboration with leading medical institutions and advisory boards of experts in the field of obesity.
The Optifast meal replacement products include shakes, soups, and bars delivering between 160 and 230 kcal per serving. The products are designed to be used as part of a total diet replacement, providing 100% of the recommended daily value for at least 24 vitamins and minerals. The program is designed to help individuals lose weight and maintain their health while receiving the necessary nutrients. The products are purchased on a biweekly basis online and picked up at a designated centre.
The Optifast program is a medically supervised weight loss journey that closely monitors and assesses an individual's progress towards better health and emotional well-being. It includes an initial comprehensive evaluation that includes a physical exam and blood tests to personalise the program for each participant. The program consists of three key phases: the Active Weight Loss phase, the Transition Phase, and the Long-Term Weight Management Phase. During the Active Weight Loss phase, participants consume a diet of Optifast full meal replacement products, including shakes, soups, and bars, totalling 800 to 1000 calories per day. This phase typically lasts for 12 or 24 weeks, during which participants receive medical monitoring and support.
In the Transition Phase, participants gradually transition back to regular foods while continuing to receive support and attend classes to help change their relationship with food and eating. The Long-Term Weight Management Phase is an ongoing process that includes partial Optifast meal replacement and partial regular food, along with ongoing support to help maintain weight loss and manage weight long-term. It is important to note that relapse is not unusual, and persistence is key to successful weight management.
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Nutritional value and clinical evidence
The OPTIFAST® Program is a medically-supervised weight loss program that includes 3 key phases designed to help patients lose weight by changing their relationship with food and eating. The program provides medical, nutritional, and behavioural support to help participants lose weight and improve their health.
OPTIFAST® products can be used as part of a total diet replacement that includes 100% of the recommended daily value of at least 24 vitamins and minerals, ensuring adequate micronutrient intake. The products are nutritionally complete and balanced, delivering between 160 and 230 kcal per serving, with 800 to 1000 calories per day. The program includes shakes, soups, and bars to replace meals and snacks, providing the recommended protein and nutrients to support health while losing weight.
The OPTIFAST® Program is clinically proven, with strong scientific evidence demonstrating its effectiveness in achieving sustainable weight loss. Clinical studies have shown that medically-monitored weight-management programs can be safe and effective in helping individuals modify behaviours and achieve long-term weight management. The program is endorsed by leading medical institutions and advisory boards of experts in the field of obesity, ensuring it adheres to high medical standards.
The OPTIFAST® Weight Loss Program is an 18-week supervised program that starts with a liquid-only diet and gradually introduces solid foods. It offers comprehensive patient education, support, counselling, and lifestyle education to promote long-term weight loss and reduce weight-related health risks. The program is designed for patients with a BMI of 30 or above or those with a BMI of 27 to 30 who have weight-related conditions such as prediabetes, diabetes, high blood pressure, high cholesterol, or sleep apnea.
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Weight loss and health benefits
The OPTIFAST® Program is a medically-supervised weight loss program that closely monitors and assesses progress towards better health and emotional well-being. The program is designed to help overweight and obese patients lose weight safely without surgical intervention. It is a total meal replacement program that includes 100% of the recommended daily value for at least 24 vitamins and minerals, ensuring you are getting all the micronutrients you need. The products are designed to be low-calorie, high-protein, and pre-portioned.
The program consists of three key phases. During the first phase, the Active Weight Loss phase, participants consume OPTIFAST® products exclusively and receive monthly medical monitoring. This phase typically lasts for 16 weeks, although there are also 12- and 24-week program options available. During this time, participants are encouraged to avoid exercising regularly at a high intensity and frequency as their bodies adjust to the new diet.
In the second, or Transition Phase, solid foods are gradually reintroduced into the diet, while patients attend classes to help change the way they think about and approach food and eating. This phase typically begins around week 10 for the 12-week program option and week 18 for the 24-week option, with expert guidance provided to help navigate the transition.
The third phase is the Long-Term Weight Management Phase, which is ongoing and can include a partial OPTIFAST® meal replacement and partial regular food, along with ongoing support. This phase focuses on helping individuals address and modify behaviours to encourage long-term weight management through nutrition, exercise, and lifestyle changes. It is important to note that weight regain after the program is not unusual, and persistent adherence to healthy habits is key.
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Optifast's program phases
The Optifast program is a medically-supervised weight loss program that closely monitors and assesses progress towards better health and emotional well-being. It is designed for people with a Body Mass Index (BMI) greater than 30, or for people with weight-related medical conditions who have a BMI greater than 28. The program is flexible and allows users to choose from 3 to 4 levels, tailoring their weight loss plan to their goals.
The Optifast plan consists of three phases: the Intensive Phase, the Transition Phase, and the Stabilization Phase. The Intensive Phase is the first phase of the Optifast plan and is generally followed for 12 to 16 weeks. During this phase, patients restrict their carbohydrate and total energy intake, typically consuming 800-1280 calories per day. Patients who actively participated in a 26-week medically-monitored program typically lost about 13.5kg. If, after 12 weeks, a patient still has significant weight to lose, they can follow the Transition Phase for a minimum of 2 weeks before repeating the Intensive Phase.
During the Transition Phase, patients replace one Optifast meal with a regular, healthy meal. During this phase, patients generally continue to lose weight but at a slower rate. Some people may experience a slight weight gain, typically of about 2 pounds, when carbohydrates are added back into the diet.
The final phase of the Optifast program is the Stabilization Phase. During this phase, patients continue to receive ongoing monitoring and education to ensure long-term weight management. Eating vegetables and fruit during this phase helps with the transition to a balanced, calorie-controlled diet. Patients who continue to use weight maintenance programs after completing Optifast have a greater chance of keeping the weight off long-term.
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Optifast's safety and effectiveness
Optifast is a clinically proven, medically endorsed weight loss program that has been shown to help people achieve sustainable weight loss. The program is designed to be safe and effective, providing medical, nutritional, and behavioural support to help individuals lose weight and improve their health. It is a comprehensive program that includes a partial or total meal replacement plan with shakes, soups, and bars delivering between 160 and 230 kcal per serving, providing 800 to 1000 calories per day. The program also includes lifestyle education, counselling, and support to help individuals change their relationship with food and make long-term lifestyle changes.
The Optifast program is designed to be safe for individuals with a body mass index (BMI) of 30 or above, or those with a BMI of 27 to 30 who have weight-related conditions such as prediabetes, diabetes, high blood pressure, high cholesterol, sleep apnea, joint pain, or liver disease. The program is also suitable for individuals who want support in overcoming emotional barriers to weight loss. It is important to note that Optifast is a medically supervised program, and participants are closely monitored by medical professionals to ensure their safety and address any health concerns.
The effectiveness of the Optifast program has been demonstrated in various studies, including the OPTIWIN Study, which compared the Optifast program to a food-based (FB) dietary plan for weight loss. The study found that the Optifast program was effective in helping participants lose weight, with some individuals losing more than 12% of their body weight at 6 months. Additionally, participants in the Optifast program experienced lower blood pressure, total cholesterol, and blood sugar levels. The program's partial or total meal replacement plan, in conjunction with comprehensive patient education and support, has been key to its effectiveness.
However, it is important to note that some individuals may struggle to follow the program due to the rapid and drastic lifestyle changes it entails. Additionally, there have been concerns about long-term weight loss maintenance after completing the program. While the program provides ongoing support and encourages periodic or continuous involvement in a weight management program, some individuals may find it challenging to maintain healthy habits and are prone to relapsing. Overall, the Optifast program has been shown to be safe and effective for individuals seeking a comprehensive, medically supervised weight loss program, but long-term commitment and persistence are crucial for sustained results.
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Frequently asked questions
The Optifast diet is a meal replacement program that includes shakes, soups, and bars delivering between 160 and 230 kcal per serving. It is designed to help people lose weight and improve their health through a combination of medical, nutritional, and behavioral support.
The Optifast diet is a medically-supervised program that includes three key phases: the Active Weight Loss phase, the Transition phase, and the Long-Term Weight Management phase. During the Active Weight Loss phase, participants consume Optifast products as a total meal replacement. In the Transition phase, self-prepared foods are gradually reintroduced, along with ongoing support. The Long-Term Weight Management phase includes partial meal replacement and regular food, along with continued support to maintain weight loss.
The Optifast diet is generally considered safe and is medically endorsed. It is designed to be clinically proven, nutritionally complete, and balanced. The program is closely monitored by medical professionals to ensure the safety and well-being of participants. However, it is always recommended to consult with a healthcare provider before starting any weight loss program.
The Optifast diet is suitable for individuals with a body mass index (BMI) of 30 or above. It may also be suitable for those with a BMI of 27 to 30 who have weight-related conditions such as prediabetes, diabetes, high blood pressure, high cholesterol, or sleep apnea. The program is designed to address both weight loss and emotional well-being.
The Optifast diet has been shown to be effective in helping individuals lose weight and improve their health. Participants in the program have experienced lower blood pressure, cholesterol, and blood sugar levels. The program also provides comprehensive support, including medical, nutritional, behavioral, and lifestyle guidance, to help individuals make long-term lifestyle changes and maintain weight loss.











































