
Diet pills that curb your appetite are known as appetite suppressants. They work by lessening your appetite or making you feel full faster, so you may take in fewer calories and lose weight. There are prescription and over-the-counter (OTC) appetite suppressants. Prescription appetite suppressants can be for long-term or short-term use, and include drugs such as Liraglutide (Saxenda), Semaglutide (Wegovy), Naltrexone-bupropion (Contrave), and Phentermine-topiramate (Qsymia). Popular OTC appetite suppressants include Garcinia Cambogia, saffron extract, bitter orange supplements, and Hoodia gordonii. However, it is important to consult a healthcare provider before using any diet pills, as they may interact with medications or cause health problems.
| Characteristics | Values |
|---|---|
| Prescription appetite suppressants | Liraglutide (Saxenda), Semaglutide (Wegovy), Naltrexone-bupropion (Contrave), Phentermine-topiramate (Qsymia), Benzphetamine (Didrex, Regimex), Diethylpropion (Tenuate, Tenuate Dospan) |
| Over-the-counter appetite suppressants | Garcinia Cambogia, Saffron extract, Bitter orange supplements, Hoodia gordonii, Guar gum |
| Prescription appetite suppressants (short-term use only) | Benzphetamine (Didrex, Regimex), Diethylpropion (Tenuate, Tenuate Dospan) |
| Prescription appetite suppressant (weekly injection) | Tirzepatide (Zepbound) |
| Prescription appetite suppressant (daily injection) | Liraglutide (Saxenda) |
| Prescription appetite suppressant (pill) | Naltrexone/bupropion (Contrave), Phentermine |
| Prescription appetite suppressant (daily injection, rare genetic conditions) | Setmelanotide (Imcivree) |
| Prescription appetite suppressant (not an appetite suppressant) | Orlistat (Xenical) |
| Prescription appetite suppressant (GLP-1 agonist) | Exenatide (Byetta) |
| Prescription appetite suppressant (tablet, twice a day) | Contrave |
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What You'll Learn

Prescription appetite suppressants
There are several prescription appetite suppressants available, including Liraglutide (Saxenda®), which is an under-the-skin injection medication. Semaglutide (Wegovy®) is another prescription appetite suppressant that comes in the form of an injection. Naltrexone-bupropion (Contrave®) is a pill that may affect the reward system in the brain, reducing the pleasure derived from eating certain foods. Phentermine-topiramate (Qsymia®) is also a pill that combines two drugs: phentermine, a stimulant that curbs appetite, and topiramate, a drug used for seizures and headaches that may also contribute to weight loss. Other prescription appetite suppressants include benzphetamine (Didrex®, Regimex®), diethylpropion (Tenuate®, Tenuate Dospan®), and phendimetrazine (Prelu-2®).
It is important to note that prescription appetite suppressants are not a standalone solution for weight loss. They are most effective when combined with a reduced-calorie eating plan and regular physical activity. Additionally, they may have side effects and interact with other medications, so it is crucial to consult a healthcare provider before taking them.
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Over-the-counter (OTC) appetite suppressants
Appetite suppressants are a type of weight-loss medication for people with obesity (a body mass index, or BMI, over 30). They affect how your body and brain experience appetite and hunger, making you feel less hungry or full faster after eating less food.
There are prescription and over-the-counter (OTC) appetite suppressants. OTC appetite suppressants may interact with medications or cause health problems, so it is important to check with your healthcare provider before using them. Here are some of the most common OTC appetite suppressants:
Garcinia Cambogia
Garcinia cambogia is one of the most popular weight loss supplements on the market. It is made with an extract derived from the peel of the Garcinia gummi-gutta fruit. Garcinia cambogia extract contains hydroxycitric acid (HCA), which may reduce appetite by increasing serotonin levels in your brain and reducing carbohydrate metabolism. A review of 12 studies found that participants who took supplements containing 1,000–2,800 mg of HCA per day for 2–12 weeks lost an average of 1.94 pounds (0.88 kg) more than those who took a placebo.
Saffron Extract
Saffron extract has been shown to reduce snacking and promote weight loss. One study in 60 overweight women found that those taking 176 mg of saffron extract per day experienced a significant reduction in snacking and lost more weight than those on a placebo pill. However, larger and longer-term studies are needed to fully understand saffron's role in appetite reduction and weight loss. Saffron extract is generally well-tolerated but may cause side effects such as dizziness, fatigue, dry mouth, anxiety, nausea, and headaches in some people.
Bitter Orange
Bitter orange supplements are marketed as a way to promote weight loss by reducing appetite. They are believed to increase basal metabolic rate and stimulate fat breakdown, leading to suppressed appetite and increased calories burned. However, research on the effectiveness of bitter orange for weight loss is inconclusive, and it is often combined with other compounds, such as caffeine, making it difficult to interpret its effectiveness.
Hoodia Gordonii
Hoodia gordonii is used in dietary supplements that claim to reduce appetite and boost weight loss. Some scientists believe it may be linked to a compound called P57 or glycoside, which may impact the central nervous system and decrease appetite. However, there is little evidence to support the use of Hoodia gordonii for weight loss or reduced appetite, and it may lead to side effects such as headaches, nausea, increased heart rate, high blood pressure, and impaired liver function.
Green Coffee Bean Extract
Green coffee bean extract has been shown to reduce appetite and promote weight loss. An analysis of three studies found that overweight participants who took 180 or 200 mg per day of green coffee extract for up to 12 weeks experienced an average weight loss of 6 pounds (2.47 kg) more than those taking placebos. It is generally well-tolerated but may cause headaches and increased heart rate in some individuals.
Other OTC appetite suppressants include Conjugated Linoleic Acid (CLA), Guarana, and various supplements available on Amazon and Walmart, such as DR VITAMIN SOLUTIONS Appetite Suppressant, Zantrex SkinnyStix Energy Powder, and Pro Health Keto ACV Gummies. However, it is important to note that there is no OTC appetite suppressant that has been proven safe and effective, and some supplements sold as appetite suppressants may do more harm than good. Always consult with your healthcare provider before taking any OTC appetite suppressant.
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Natural appetite suppressants
Exercise
Exercise releases endorphins, hormones that can reduce stress and improve your mood, which can help keep you from stress eating. Exercise can also suppress hunger hormones. The current guidelines recommend 150 minutes a week of moderate-intensity cardio exercise, or half an hour of exercise five days a week. You should also aim to do some strength training at least twice a week for 15 minutes at a time.
Sleep
Too little sleep can increase your stress levels, which can stimulate your appetite. Sleep is, therefore, a form of natural appetite suppression.
Water
Drinking enough water is one of the healthiest habits to develop. Water is essential for your well-being and can help curb your appetite.
Foods
Foods high in protein and fibre can help suppress your appetite. Lean proteins and high-fibre foods take longer to digest, so they'll keep you fuller for longer. Whole grains and strawberries are examples of such foods.
Herbs and plants
Some herbs and plants may help promote weight loss by slowing stomach emptying, blocking nutrient absorption, or influencing appetite hormones. Fenugreek seeds contain both soluble and insoluble fibre, which can increase feelings of fullness and lead to lower food intake. However, more research is needed to confirm the benefits of fenugreek.
Other supplements
Some other natural appetite suppressants include saffron extract, glucomannan, Gymnema sylvestre, Griffonia simplicifolia, Caralluma fimbriata, green tea, and yerba mate. However, it is important to note that there is little evidence to support the effectiveness of natural appetite suppressant supplements, and they can sometimes be harmful. Always consult a doctor before taking any supplements.
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Appetite suppressant side effects
Appetite suppressants, also known as "diet pills," are a type of weight-loss medication that affects your brain's urge to eat. They work by reducing or curbing hunger pangs or by making you feel fuller faster with less food. As a result, you eat less, consume fewer calories, and lose weight.
There are prescription and over-the-counter (OTC) appetite suppressants. Prescription appetite suppressants can be for long-term or short-term use. Long-term prescription appetite suppressants are generally safe if taken as prescribed, but short-term prescription appetite suppressants require more caution due to possible severe side effects and addiction potential. Some prescription appetite suppressants that have been approved by the FDA for long-term use include Liraglutide (Saxenda) and Semaglutide (Wegovy). Naltrexone-bupropion (Contrave) and Phentermine-topiramate (Qsymia) are examples of prescription appetite suppressants for short-term use.
While appetite suppressants can be effective for weight loss, they also come with side effects and risks. Each type of appetite suppressant has different side effects, and some may interact with other medications. Common side effects of short-term prescription appetite suppressants include rapid or irregular heartbeat, mood changes such as depression or anxiety, cognitive changes like agitation or delirium, nausea, vomiting, diarrhoea, constipation, and abdominal pain. Long-term use of appetite suppressants may also carry health risks, especially if taken for longer than 12 weeks.
Some over-the-counter appetite suppressants may contain stimulants, which can have the opposite effect and keep you awake. Additionally, some OTC appetite suppressants may contain ephedra, ephedrine, or caffeine, and have been linked to reports of heart attack, seizure, stroke, and even death. It is important to consult with a healthcare provider before taking any OTC appetite suppressants to ensure they are safe and do not interact with any medications you may be taking.
It is always recommended to consult with a healthcare professional before starting any new medication, including appetite suppressants, to ensure they are suitable for your individual needs and health status.
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Appetite suppressant alternatives
Appetite suppressants can help with weight loss for people with obesity. They work by lessening your appetite or making you feel full faster. There are prescription and over-the-counter (OTC) appetite suppressants.
Prescription Appetite Suppressants
The Food and Drug Administration (FDA) has approved the following prescription appetite suppressants for long-term use:
- Liraglutide (Saxenda®)
- Semaglutide (Wegovy®)
- Tirzepatide (Zepbound)
- Naltrexone-bupropion (Contrave®)
- Phentermine-topiramate (Qsymia®)
The following prescription appetite suppressants are for short-term use only, typically up to 12 weeks (three months):
- Benzphetamine (Didrex®, Regimex®)
- Diethylpropion (Tenuate®, Tenuate Dospan®)
- Phendimetrazine (Prelu-2®)
- Phentermine (Dipex-P®, Atti-Plex P®, Pro-Fast®)
Over-the-Counter Appetite Suppressants
There are no over-the-counter appetite suppressants that have been proven safe and effective. Some supplements sold as appetite suppressants may do more harm than good.
Some examples of over-the-counter appetite suppressants include:
- Garcinia Cambogia: This supplement contains hydroxycitric acid (HCA), which may reduce appetite by increasing serotonin levels in your brain and reducing the metabolism of carbohydrates.
- Saffron Extract: Saffron extract may reduce hunger and aid in weight loss.
- Bitter Orange: This supplement is believed to increase the basal metabolic rate, stimulating fat breakdown and suppressing appetite.
- Hoodia Gordonii: This supplement claims to reduce appetite and boost weight loss, but there is little evidence to support these claims.
- Conjugated Linoleic Acid (CLA): CLA is a type of polyunsaturated fatty acid naturally found in foods like dairy and beef. It may affect appetite-regulating genes and hormones, but it has not been shown to reduce appetite in humans.
- Glucomannan: This is a type of soluble fiber derived from the edible roots of the konjac plant. It can absorb up to 50 times its weight in water, increasing feelings of fullness and reducing appetite.
- Green Tea Extracts: Green tea contains substances called catechins that might have some effect on appetite and fat burning. It also contains caffeine, a stimulant that can affect appetite.
Alternative Strategies
If you are truly hungry, you should eat something. But consider whether what you're feeling is thirst, in which case, drinking water may help. If you are experiencing a craving, try a distraction like a brisk walk outside. Eating filling foods with fiber and protein can also help curb your appetite. Additionally, finding the best eating times for you and getting enough sleep may help reduce your appetite.
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Frequently asked questions
Appetite suppressants are a type of weight-loss medication for people with obesity (a body mass index or BMI over 30). They work by lessening your appetite or making you feel full faster.
Prescription appetite suppressants include Liraglutide (Saxenda), Semaglutide (Wegovy), Naltrexone-bupropion (Contrave), and Phentermine-topiramate (Qsymia).
Some OTC appetite suppressants include Garcinia Cambogia, saffron extract, bitter orange supplements, and Hoodia gordonii. However, it's important to consult your healthcare provider before taking any OTC diet pills as they may have side effects or interact with medications.
It's important to consult your doctor to determine if prescription weight loss drugs are suitable for you. They can help you explore the effectiveness, risks, and benefits to make an informed decision about your weight loss journey.
Yes, each appetite suppressant may have side effects and risks. For example, saffron extract may cause dizziness, fatigue, dry mouth, anxiety, nausea, and headaches in some individuals. Contrave, a prescription appetite suppressant, has a boxed warning about an increased risk of suicidal thoughts and behaviours associated with one of its ingredients, bupropion.











































