Milly Gaines
DMAA, or 1,3-dimethylamylamine, is a controversial amphetamine derivative that has been marketed as a dietary supplement for weight loss and athletic performance enhancement. It is often sold as a pre-workout supplement and has been associated with serious health risks, including increased heart rate, high blood pressure, and even cerebral hemorrhage. Due to safety concerns, the FDA considers DMAA to be an unsafe food additive and has taken actions to remove DMAA-containing products from the market. Despite these efforts, DMAA continues to be found in some diet pills and supplements, with manufacturers claiming that it occurs naturally in plants like geranium or rose geranium oil. However, there is no reliable scientific evidence to support these claims, and consumers are advised to refrain from purchasing or consuming any product containing DMAA.
| Characteristics | Values |
|---|---|
| What is DMAA? | DMAA (1,3-dimethylamylamine) is an amphetamine derivative that has been marketed in sports performance and weight loss products, many of which are sold as dietary supplements. |
| Is DMAA safe? | The FDA does not have any information to demonstrate that consuming DMAA is safe. When DMAA is added to a product marketed as a dietary supplement, the FDA considers it to be an unsafe food additive. |
| What does DMAA do to the body? | DMAA narrows blood vessels and arteries, which can raise blood pressure, and may lead to cardiovascular problems such as shortness of breath, arrhythmias, tightening in the chest, and heart attack, as well as seizures and other neurological and psychological conditions. |
| What are DMAA's other names? | Methylhexanamine, geranium extract, geranamine, floradrene, metexaminum, methexaminum, methylhexanamine, and many more. |
| What products contain DMAA? | OxyElite Pro, Jack3d, Hydroxystim, and Hi-Tech Pharmaceuticals. |
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What You'll Learn
DMAA is not a dietary ingredient and is unsafe to consume
DMAA, or 1,3-dimethylamylamine, is a synthetic stimulant that has been marketed as a dietary supplement in sports performance and weight loss products. Despite this, DMAA is not a dietary ingredient and is not recognised as safe to consume.
DMAA is an amphetamine derivative that is known to narrow blood vessels and arteries, which can lead to increased blood pressure and cardiovascular problems. These problems can include shortness of breath, tightening in the chest, arrhythmias, seizures, and even heart attack. The FDA has stated that there is no information to demonstrate that consuming DMAA is safe and considers it to be an unsafe food additive. The FDA has been working to remove DMAA-containing products from the market and advises consumers not to purchase or use any product containing DMAA.
The safety of DMAA has been questioned due to a number of adverse events and several deaths reported in association with its use. It has been linked to serious health issues such as strokes, heart disease, liver failure, and even sudden death. In addition, DMAA can interact with other stimulant drugs, such as caffeine, increasing the risk of serious side effects.
Regulatory agencies and sports authorities in various countries, including Canada, Sweden, Brazil, Australia, and the UK, have also taken action to ban or restrict the sale of DMAA-containing products due to safety concerns. The USPLabs company, for example, was forced to destroy DMAA-containing products worth over $8 million in 2013.
In summary, DMAA is not a dietary ingredient and consuming it poses significant health risks. Consumers are strongly advised to avoid purchasing or using any products containing DMAA and to report any adverse events to the relevant authorities.
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DMAA is a sympathomimetic and potent pressor agent
DMAA, or 1,3-dimethylamylamine, is a synthetic, sympathomimetic aliphatic amine with potent pressor action. It is structurally similar to amphetamines and has stimulant properties. DMAA is not a dietary ingredient and has been associated with adverse effects, including increased heart rate, high blood pressure, and cardiovascular problems.
DMAA was initially developed in 1944 as a nasal decongestant but was discontinued in 1983. It resurfaced in 2006 as a component of dietary supplements for weight loss and exercise, often marketed as a "natural" stimulant. DMAA has stimulant effects and can speed up the nervous system, similar to stimulant drugs such as amphetamine, caffeine, and pseudoephedrine.
The use of DMAA-containing dietary supplements has been widespread, especially among young adults seeking a legal alternative to other stimulants. It has been reported to have abuse liability, with cocaine- and methamphetamine-like discriminative stimulus effects. DMAA has been associated with serious health risks, including cerebral hemorrhage and death. Regulatory agencies worldwide have taken action to remove DMAA products from the market due to safety concerns.
In the United States, the Food and Drug Administration (FDA) has been working to get DMAA products off the market and advises consumers not to purchase or use any product containing DMAA. The FDA considers DMAA to be an unsafe food additive when added to products marketed as dietary supplements, and its marketing violates the law. DMAA narrows blood vessels and arteries, leading to increased blood pressure and potential cardiovascular problems, including shortness of breath, chest tightening, and heart attack.
Due to the health risks and lack of evidence demonstrating its safety, consumers should exercise caution and avoid purchasing or consuming any products containing DMAA.
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DMAA narrows blood vessels and arteries, raising blood pressure
DMAA, or 1,3-dimethylamylamine, is a stimulant and vasoconstrictor, meaning that it narrows blood vessels and arteries, which can lead to an increase in blood pressure.
DMAA is often marketed as a dietary supplement for weight loss and sports performance, but it is not a dietary ingredient. The FDA has stated that it is an unsafe food additive and has been working to get DMAA products off the market. The administration advises consumers not to purchase or use any product containing DMAA due to associated health risks.
When taken, DMAA can speed up the nervous system, which can make individuals feel jittery and increase their heart rate. It can also decrease how quickly the liver breaks down certain medications, increasing their effects and side effects.
The health risks associated with DMAA are serious and include cardiovascular problems such as shortness of breath, arrhythmias, tightening in the chest, and heart attack. It has also been linked to seizures, liver injury, stroke, brain hemorrhage, and death.
DMAA is known to have caused numerous adverse events and at least five deaths. It is banned by many sports authorities and governmental agencies, and its use is prohibited for military service members.
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The FDA has taken action to get DMAA products off the market
DMAA, or 1,3-dimethylamylamine, is an amphetamine derivative that has been marketed in sports performance and weight loss products, many of which are sold as dietary supplements. DMAA is not a dietary ingredient, and the FDA considers DMAA-containing products marketed as dietary supplements to be illegal. The FDA does not have any information to demonstrate that consuming DMAA is safe. When DMAA is added to a product marketed as a dietary supplement, the FDA considers it to be an unsafe food additive.
The FDA has been working to get DMAA products off the market and advises consumers not to purchase or use any product containing DMAA. This substance narrows blood vessels and arteries, which can raise blood pressure and lead to cardiovascular problems such as shortness of breath, arrhythmias, tightening in the chest, and heart attack, as well as seizures and other neurological and psychological conditions.
Starting in 2012, the FDA has issued warning letters to companies notifying them that marketing DMAA-containing products violates the law. When products containing DMAA are found during facility inspections, the FDA discusses its concerns with the firms and gives them an opportunity to voluntarily recall and destroy these products. Most companies warned are no longer distributing products with DMAA. When firms have chosen not to comply voluntarily, the FDA has taken other actions, such as administratively detaining DMAA-containing products.
In 2013, the FDA detained two DMAA-containing products, OxyElite Pro and Jack3d, after USPLabs initially refused the FDA’s efforts to achieve voluntary compliance. USPLabs ultimately destroyed the detained products and agreed to stop manufacturing with DMAA. Also in 2013, the FDA seized DMAA-containing products from Hi-Tech Pharmaceuticals. A federal district court ruled in April 2017 that the products were adulterated and ordered them condemned and forfeited for destruction. In 2019, the U.S. Court of Appeals affirmed the lower court ruling, finding that DMAA is not a dietary ingredient and is not generally recognized as safe.
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DMAA is often marketed as a dietary supplement
DMAA, or 1,3-dimethylamylamine, is a pharmaceutical amphetamine derivative that has been marketed in sports performance and weight loss products, many of which are sold as dietary supplements. DMAA is not a dietary ingredient, and the FDA considers products containing DMAA and marketed as dietary supplements to be illegal.
DMAA is often touted as a "natural" stimulant, but the FDA is not aware of any reliable science indicating that DMAA exists naturally in plants. It has been estimated that DMAA is present in more than 200 supplements, despite reports of the agent's association with hemorrhagic strokes and death. Some products claim that DMAA naturally occurs in rose geranium oil, but laboratory analysis shows that this drug probably does not come from this natural source. It is thought that manufacturers have artificially added this drug to the supplement rather than obtaining it from a natural source.
DMAA was originally introduced in 1948 as a nasal inhaler for rhinitis by Eli Lilly & Co. and was later used as a nasal decongestant. However, by the 1970s, it had been withdrawn as an approved pharmaceutical. Today, DMAA is sold as a dietary supplement used for attention deficit-hyperactive disorder (ADHD), weight loss, improving athletic performance, and bodybuilding. It is also sold as a recreational stimulant drug, with its use becoming increasingly prevalent among young adults, especially those seeking a legal alternative to other drugs.
The FDA does not have any information to demonstrate that consuming DMAA is safe. When DMAA is added to a product marketed as a dietary supplement, the FDA considers it to be an unsafe food additive. The FDA advises consumers not to purchase or use any product containing DMAA, as it can narrow blood vessels and arteries, which can raise blood pressure and lead to cardiovascular problems such as shortness of breath, arrhythmias, tightening in the chest, and heart attack. Taking DMAA along with stimulant drugs may also cause serious problems, including increased heart rate and high blood pressure.
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Frequently asked questions
DMAA (1,3-dimethylamylamine) is an amphetamine derivative that has been marketed in sports performance and weight loss products, many of which are sold as dietary supplements.
No. The FDA does not have any information to demonstrate that consuming DMAA is safe. When DMAA is added to a product marketed as a dietary supplement, the FDA considers it to be an unsafe food additive. The FDA advises consumers not to purchase or use any product containing DMAA.
DMAA narrows blood vessels and arteries, which can raise blood pressure and lead to cardiovascular problems such as shortness of breath, arrhythmias, tightening in the chest, and heart attack, as well as seizures and other neurological and psychological conditions.
DMAA has been found in products such as OxyElite Pro, Jack3d, and Hydroxystim. It is estimated that DMAA is present in more than 200 supplements despite reports of the agent's association with hemorrhagic strokes and death.
