
Diet pills, also known as weight loss medications, can be broken down into three groups: appetite suppressants, stimulants, and fat blockers. While they can be effective in aiding weight loss, they can also have adverse side effects, especially when it comes to the gastrointestinal system. Diet pills can cause nausea, vomiting, diarrhoea, constipation, and stomach pain. Some diet pills have also been found to have antibacterial effects on the human intestinal microbiota. It is important to consult a doctor before taking any kind of diet pill, as they can be addictive and dangerous if not used as intended.
| Characteristics | Values |
|---|---|
| Purpose | To suppress appetite, make you feel full faster, and reduce food intake |
| Common Ingredients | Phentermine, Topiramate, Bupropion, Naltrexone, Orlistat, Diethylpropion, Phendimetrazine, Liraglutide, Lorcaserin, Sibutramine, Benzphetamine |
| Side Effects | Nausea, Vomiting, Diarrhea, Constipation, Stomach Pain, Dry Mouth, Racing Heart, Increased Blood Pressure, Insomnia, Kidney Damage, Pancreatitis, Gallbladder Problems, Allergic Reaction, High Blood Pressure, Heart Valve Diseases, Withdrawal Symptoms |
| Effectiveness | Prescription weight loss medications can result in a 5% to 10% loss of body weight, with newer treatments showing up to 20% weight loss |
| Usage | Should be combined with a reduced-calorie diet and regular physical activity for best results and to minimize weight regain |
| Addiction | Diet pills can be addictive, and users may develop a substance use disorder |
| Types | Appetite Suppressants, Stimulants, Fat Blockers |
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What You'll Learn

Appetite suppressants
There are prescription and over-the-counter (OTC) appetite suppressants. Prescription appetite suppressants can be for long-term or short-term use. The Food and Drug Administration (FDA) has approved the following prescription appetite suppressants for long-term use: Liraglutide (Saxenda®), an under-the-skin (subcutaneous) injection medication; Semaglutide (Wegovy®), an under-the-skin injection medication; Naltrexone-bupropion (Contrave®), a pill; and Phentermine-topiramate (Qsymia®). Other prescription appetite suppressants include Diethylpropion (Tenuate®, Tenuate Dospan®), Phendimetrazine (Prelu-2®), and Phentermine (Dipex-P®, Atti-Plex P®, Pro-Fast®). These short-term appetite suppressants are controlled substances, meaning they have addiction potential and can be dangerous if used outside of their prescribed use.
Some over-the-counter appetite suppressants may interact with medications or cause health problems. It is important to check with a healthcare provider before using OTC appetite suppressants. Studies show that prescription appetite suppressants are most beneficial for weight loss when combined with a reduced-calorie eating plan and regular physical activity. Weight loss medications should be used alongside a low-calorie diet and a doctor-approved exercise plan for best results.
Common side effects of prescription weight loss drugs include nausea, vomiting, diarrhea, constipation, stomach pain, and injection site reactions. Other less common but more serious side effects include allergic reactions, pancreatitis, gallbladder problems, kidney damage, blurred vision, increased heart rate, and suicidal thoughts.
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Fat blockers
Diet pills, also known as appetite suppressants, are a type of weight-loss medication for people with obesity (a body mass index, or BMI, over 30). They work by lessening your appetite or making you feel full faster, which results in reduced calorie intake and weight loss.
One of the most well-known types of diet pills is Orlistat (prescription and nonprescription). Orlistat, also known by the brand names Xenical and Alli, is a fat blocker that works by inhibiting the absorption of fat in the intestines. It prevents approximately a third of the fat consumed from being absorbed, and this unabsorbed fat is then eliminated from the body through stool.
Orlistat is typically taken as a capsule three times a day with each main meal that contains fat. It can be taken during a meal or up to an hour after eating. If a meal is missed or does not contain fat, the dose can be skipped. It is important to note that Orlistat should be combined with a low-fat diet (less than 30% of daily calories from fat) to minimize side effects.
Additionally, Orlistat blocks the absorption of some fat-soluble vitamins and beta carotene. Therefore, it is recommended to take a daily multivitamin containing vitamins A, D, E, K, and beta-carotene when using Orlistat. The multivitamin should be taken at least two hours before or after taking Orlistat to ensure effective nutrient absorption.
It is always advisable to consult a healthcare provider before starting any weight-loss medication, including Orlistat. They can help determine if Orlistat is suitable for you and provide guidance on dosage, diet, and potential side effects.
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Prescription vs. over-the-counter
Diet pills, also known as appetite suppressants, are weight-loss medications that affect how your body and brain experience appetite and hunger. They work by blocking or increasing specific hormones, neurotransmitters, and/or peptides. They can make you feel less hungry or make you feel full faster after eating less food.
Prescription appetite suppressants can help with weight loss for people with obesity, especially when modified eating plans and increased exercise alone haven't helped. They are recommended for people with a body mass index (BMI) of 30 or higher, or a BMI greater than 27 with weight-related health problems. Prescription appetite suppressants can be for long-term or short-term use, and include medications such as:
- Liraglutide (Saxenda®)
- Semaglutide (Wegovy®)
- Naltrexone-bupropion (Contrave®)
- Phentermine-topiramate (Qsymia®)
- Orlistat (Xenical)
- Benzphetamine (Didrex™)
- Diethylpropion (Tenuate™)
- Phentermine (Adipex-P, ProFast)
- Phendimetrazine (Prelu-2®)
Over-the-counter (OTC) appetite suppressants are also available without a prescription. However, it is important to consult a healthcare provider before using these products as they may interact with medications or cause health problems. The only FDA-approved OTC medicine for weight loss is Alli (orlistat), which is available at a lower dose than its prescription counterpart, Xenical. Other OTC products are considered supplements, which are not regulated by the FDA and lack proper studies to confirm their safety and effectiveness.
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Side effects
Diet pills can have several side effects, and these differ depending on the type of pill. Appetite suppressants, stimulants, and fat blockers are the three main types of diet pills. Each has its own set of side effects in the short and long term.
Appetite Suppressants
Appetite suppressants work by reducing your appetite or making you feel full faster. They target the chemical neurotransmitters in your brain, such as serotonin and norepinephrine, to help you feel full so you don't eat as much. These chemicals also target the pleasurable associations with food to help decrease your appetite. Some common appetite suppressants include Liraglutide, Lorcaserin, Sibutramine, Bupropion, and Naltrexone, which are marketed under trade names such as Contrave, Saxenda, and Belviq. Prescription appetite suppressants can be for long-term or short-term use, and they can be addictive if not used as intended.
Stimulants
Stimulants are another type of diet pill that can cause dependence, and users may need to increase their dosage over time to achieve the same effect. They can also lead to an overdose, similar to a meth or cocaine overdose, which can cause heart failure. Short-term side effects of stimulants include dry mouth, constipation, a racing heart, increased blood pressure, insomnia, and appetite suppression. Long-term effects can be more damaging, including high blood pressure and heart valve disease. Withdrawal symptoms may also occur if you stop taking stimulants.
Fat Blockers
Fat blockers' side effects primarily affect the gastrointestinal system. The more fat or greasy foods you eat, the worse your gastrointestinal side effects will be. Fat blockers can cause diarrhea, nausea, vomiting, and stomach pain. Orlistat (Xenical) is an example of a fat blocker that blocks your body from absorbing about a third of the fat you eat. While these side effects are generally mild and temporary, they may worsen with a high-fat diet. Rare cases of severe liver injury have been reported with Orlistat, although it is unclear if the drug caused these issues.
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Withdrawal
Diet pills can be addictive and dangerous. They can rewire the brain's risk and reward centres, making withdrawal intense and severe. Withdrawal symptoms can begin as soon as six hours after the last dose, with most people experiencing the first signs of physical withdrawal within 36 hours. Symptoms will peak within the first five to seven days and then gradually taper off. However, cravings for the drugs can persist for years.
Therapists are also available to assist those with anxiety and body image issues to recover from an eating disorder and diet pill addiction. A cold-turkey detox is not recommended as the body can go into shock when the substance it has been using to function is taken away. Withdrawal symptoms are intense and can put the person at risk of relapse and severe health consequences.
Diet pills can be broken down into three groups: appetite suppressants, stimulants, and fat blockers. Appetite suppressants can cause constipation, abdominal pain, indigestion, rapid or irregular heartbeat, mood changes, cognitive changes, nausea, vomiting, diarrhoea, and abdominal pain. Stimulants can lead to insomnia, increased blood pressure, a fast heart rate, restlessness, drug dependence, abuse, and withdrawal symptoms. Fat blockers can cause oily spotting, gas, and soft stools.
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Frequently asked questions
Diet pills are weight loss medications that fall into three groups: appetite suppressants, stimulants, and fat blockers. Appetite suppressants work by lessening your appetite or making you feel full faster. Stimulants can be addictive and have side effects such as dry mouth, constipation, racing heart, increased blood pressure, and insomnia. Fat blockers prevent your body from absorbing fat, but they can have unpleasant gastrointestinal side effects.
The side effects of diet pills on the intestines vary depending on the type of pill. Fat blockers, in particular, can have unpleasant gastrointestinal side effects, especially if you consume a lot of fatty or greasy foods. Other diet pills may cause nausea, vomiting, diarrhea, and constipation.
Diet pills are not safe for everyone and should only be taken under the supervision of a healthcare professional. They can have serious side effects and may interact with other medications. It is important to consult your doctor before taking any diet pills, especially if you have a substance use disorder or a family history of substance use disorders.











































