
Diet pills, or weight loss medications, are pharmacological agents that reduce or control excess body fat. They are designed to alter one of the fundamental processes of the human body, weight regulation, by reducing appetite and energy intake, increasing energy expenditure, redirecting nutrients from adipose to lean tissue, or interfering with the absorption of calories. Diet pills are intended to be used in conjunction with a healthy diet and exercise regimen, and they can be administered orally or via injection. While they can aid in weight loss, it's important to consult a healthcare professional before use, as they may interact with other medications or cause health problems.
| Characteristics | Values |
|---|---|
| Purpose | Reduce or control excess body fat |
| Working | Reducing appetite, increasing energy expenditure, redirecting nutrients from adipose to lean tissue, or interfering with the absorption of calories |
| Usage | Should be used in combination with a healthy diet and exercise |
| Effectiveness | Studies show that weight management medications work best when combined with a lifestyle program |
| Types | Prescription and over-the-counter (OTC) appetite suppressants, injections, capsules |
| Side Effects | Oily discharge from the rectum, flatus with discharge, increased defecation, fecal incontinence, steatorrhea |
| Precautions | Never take weight management medications during pregnancy or if you are planning a pregnancy |
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What You'll Learn

Appetite suppressants
There are prescription and over-the-counter (OTC) appetite suppressants. Prescription appetite suppressants can be for long-term or short-term use, and it is important to consult a healthcare provider before taking them. Certain prescription appetite suppressants have been approved by the Food and Drug Administration (FDA) for long-term use. These include Liraglutide (Saxenda®), an injectable medication, and Semaglutide (Wegovy®), also an injectable medication. Naltrexone-bupropion (Contrave®) and Phentermine-topiramate (Qsymia®) are examples of prescription appetite suppressant pills approved by the FDA. Other prescription appetite suppressants, such as Benzphetamine (Didrex®, Regimex®), Diethylpropion (Tenuate®, Tenuate Dospan®), and Phendimetrazine (Prelu-2®), are approved for short-term use only, typically up to 12 weeks, due to their potential for addiction and misuse.
Over-the-counter appetite suppressants are also available, but caution is advised as they may interact with medications or cause health problems. Popular ingredients in OTC appetite suppressants include green tea extract, chromium, caffeine, glucomannan, and berberine. These products are often marketed as weight loss or fat-burning supplements and may be in the form of pills, powders, or gummies.
It is important to note that appetite suppressants are not a standalone solution for weight loss. Studies indicate that they are most effective when combined with a reduced-calorie diet and regular physical activity. Additionally, the complex bodily processes involved in hunger, energy, and appetite homeostasis should be considered, as they involve interactions between the brain, nervous system, hormones, neurotransmitters, and peptides.
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Prescription medications
Prescription diet pills are typically recommended for people with obesity, which is defined as having a Body Mass Index (BMI) of 30 or higher. Healthcare providers may also recommend prescription diet pills to individuals with a BMI greater than 27 who have weight-related health issues such as type 2 diabetes, high blood pressure, or high cholesterol.
Prescription diet pills are also known as appetite suppressants as they work by reducing your appetite or making you feel full faster. They can be prescribed for long-term or short-term use. The U.S. Food and Drug Administration (FDA) has approved several prescription diet pills for long-term use, including:
- Liraglutide (Saxenda)
- Semaglutide (Wegovy)
- Naltrexone-bupropion (Contrave)
- Phentermine-topiramate (Qsymia)
Other prescription diet pills approved by the FDA for short-term use include:
- Benzphetamine (Didrex, Regimex)
- Diethylpropion (Tenuate, Tenuate Dospan)
- Phendimetrazine (Prelu-2)
- Phentermine (Dipex-P, Atti-Plex P, Pro-Fast)
It is important to note that prescription diet pills are not a quick fix and should be combined with lifestyle changes such as a nutritious diet and routine exercise for optimal results. Additionally, they may have side effects, and it is important to consult a healthcare professional before taking them.
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Weight loss drugs
It's important to note that weight loss drugs are intended to be used as part of a comprehensive treatment plan for obesity, which may include a healthy diet, exercise, and lifestyle changes. They should not be relied upon as the sole method for weight loss. Additionally, it is always advisable to consult with a healthcare professional before starting any weight loss medication to ensure safety and effectiveness.
Some common weight loss drugs include:
- Orlistat: A lipase inhibitor that comes in capsule form. It blocks the absorption of dietary fats by inhibiting the enzyme that breaks down fats in food. It is typically taken with a reduced-calorie diet and can cause side effects such as oily discharge and increased bowel movements.
- Liraglutide: A daily injectable medication that acts on hormones to make patients feel full quicker and reduce hunger signals. It is approved by the FDA for weight management and can lead to weight loss of 5-10% of body weight.
- Semaglutide: A medication that works by reducing appetite and is meant to be used in combination with diet and exercise. It is approved by the FDA for chronic weight management in individuals with a BMI of 30 or greater.
- Phentermine-topiramate (Qsymia): An FDA-approved prescription appetite suppressant for short-term use, typically up to 12 weeks. It has the potential for addiction and should be used with caution.
- Setmelanotide: An agonist of the melanocortin 4 receptor, indicated for chronic weight management in patients with obesity due to certain rare genetic disorders.
These medications have been shown to be effective in helping individuals lose weight, especially when combined with a healthy diet and regular physical activity. However, it is important to consult a healthcare professional to determine the most suitable medication and to monitor for any potential side effects.
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FDA-approved drugs
The U.S. Food and Drug Administration (FDA) has approved several drugs for weight loss and chronic weight management. These medications are intended to supplement a balanced weight-loss diet and healthy lifestyle, as they are not likely to be a helpful long-term solution on their own. They should only be taken under medical supervision and may have serious side effects.
Zepbound (tirzepatide) is an injectable medication approved for adults with obesity or a body mass index (BMI) of 30 or greater. It can also be used by those who are overweight (BMI of 27 or greater) with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. The recommended maintenance dosage of Zepbound is 5-15 mg, injected subcutaneously once weekly. It works by regulating hormones to suppress appetite and reduce food intake.
Contrave, a combination medication consisting of bupropion (an antidepressant) and naltrexone (an opioid antagonist), is another FDA-approved drug. It is taken orally and should be used alongside a low-calorie diet and exercise. In clinical trials, 40% of participants who took Contrave lost at least 5% of their body weight, and 20% lost at least 10%.
Other FDA-approved weight loss medications include orlistat (Xenical, Alli), phentermine-topiramate (Qsymia), liraglutide (Saxenda), semaglutide (Wegovy), and setmelanotide (IMCIVREE). Orlistat, a lipase inhibitor, reduces fat absorption in the gut. It is often a better choice for people who consume fatty foods, but no more than 30% of calories should come from fat when taking this medication. Liraglutide (Saxenda, Victoza) is also approved for adolescents and young adults who have undergone weight-loss surgery but have not achieved the expected weight loss or still have severe obesity. Semaglutide (Wegovy) is approved for adults and children aged 12 and above with obesity or some adults with excess weight and weight-related medical issues. Setmelanotide (IMCIVREE) is approved for children aged six and older with rare genetic disorders causing obesity.
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Side effects
Diet pills and weight loss supplements are associated with a range of side effects, some of which can be serious or even life-threatening. It is important to consult a healthcare professional before taking any such pills or supplements.
Diet pills often contain a blend of stimulants, herbs, and other ingredients that can cause toxicity and serious side effects. One ingredient, DNP, has been linked to several deaths and can lead to peeling skin and heart damage if used over a long period. Even pills that don't contain DNP can have dangerous side effects and are not an effective method for maintaining a healthy weight in the long term.
Some prescription appetite suppressants, such as liraglutide (Saxenda) and semaglutide (Wegovy), have been approved by the FDA for long-term use. However, these medications also carry side effects, and patients may stop taking them as a result. Short-term use of prescription appetite suppressants can lead to rapid or irregular heartbeat (tachycardia or arrhythmia), mood changes, cognitive (mental) changes, nausea, vomiting, diarrhoea, constipation, and abdominal pain.
Stimulant-type drugs like phentermine (Adipex-P) can cause insomnia, increased blood pressure, a fast heart rate, restlessness, drug dependence, abuse, and withdrawal symptoms. Drugs that interfere with fat absorption, such as orlistat (Alli), can lead to oily spotting, gas, and soft stools. Diet pills that affect neurotransmitters in the brain, such as bupropion and naltrexone (Contrave), are linked to headaches, dry mouth, dizziness, nausea, vomiting, and constipation.
Research has also found that the use of diet pills and weight loss supplements can serve as a gateway to eating disorders like anorexia or orthorexia, especially in those who already have a negative body image and an obsession with body weight.
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Frequently asked questions
Found is a weight loss program founded in 2019 by Emily Yodofsky, Swathy Prithivi, and Jack Abraham. The program offers a combination of lifestyle changes and medication to help users reach their goals.
Found offers two weight-loss approaches: the Wellness Path and the Rx Path. The Wellness Path is available to anyone and does not involve prescription drugs. The Rx Path involves prescription medication and is only available to qualifying members.
Found-affiliated providers can prescribe a wide range of medications, including some that are FDA-approved anti-obesity medications. Others are FDA-approved for other conditions and prescribed off-label to help with weight loss.
The cost of medication on Found varies. Found offers a self-pay membership that includes clinical care costs in the membership fee. Found also has partnerships with many medical insurance carriers to make care more affordable.
Yes, there are several alternatives to Found, including Calibrate, Sequence, and Everlywell. These programs offer similar services, with some variations in pricing and features.











































