Jeffrey Salazar
Weight loss medications are intended for individuals with health problems related to overweight or obesity. Healthcare providers may prescribe weight loss medication when dietary changes and exercise are insufficient. The latest prescription diet pill, Zepbound (Tirzepatide), was FDA-approved in November 2023. It is a dual GIP and GLP-1 receptor agonist that suppresses appetite, improves satiety, and supports metabolic health. In clinical trials, Zepbound demonstrated statistically significant weight loss compared to a placebo, with adults achieving up to 22.5% average body weight reduction at 72 weeks. Other FDA-approved weight loss medications include Wegovy (Semaglutide), Contrave (Naltrexone-Bupropion), and Qsymia (Phentermine-Topiramate). These medications are designed to aid weight loss in conjunction with a healthy diet and exercise.
| Characteristics | Values |
|---|---|
| Name | Zepbound (Tirzepatide) |
| Brand Name | Wegovy |
| Type | Prescription pill |
| FDA-Approved | Yes |
| Date of Approval | November 2023 |
| Average Weight Loss | 22.5% |
| Timeframe | 72 weeks |
| Side Effects | Abnormal sensations, dizziness, altered taste, insomnia, constipation, dry mouth |
| Contraindications | Uncontrolled hypertension, coronary artery disease, hyperthyroidism, glaucoma, sensitivity to stimulants |
| Dosage | 3.75 mg/23 mg to 15 mg/92 mg |
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What You'll Learn
- Tirzepatide (Zepbound) is the most effective FDA-approved prescription diet pill
- Naltrexone-bupropion is a combination of an opioid receptor antagonist and an antidepressant
- Orlistat (Xenical) is a lipase inhibitor that reduces fat absorption in the gut
- Contrave is a combination medication of bupropion and naltrexone
- Qsymia (phentermine and topiramate) is a prescription medicine for adults and children
Tirzepatide (Zepbound) is the most effective FDA-approved prescription diet pill
Prescription diet pills are one of many methods to treat obesity and being overweight. A treatment plan for obesity can include a combination of medications, diet, exercise, and even surgery. Weight management medications are meant to help people who have health problems related to being overweight or obese.
Zepbound is approved for adults with obesity or who are overweight and have weight-related medical problems or OSA (obstructive sleep apnea). It is a prescription medicine that should be used alongside a reduced-calorie diet and increased physical activity. It is injected under the skin (subcutaneously) of the stomach, thigh, or upper arm once a week, at any time of the day. It is important to change the injection site with each weekly injection.
Zepbound may cause serious side effects, including severe stomach problems, nausea, diarrhea, and vomiting, which may lead to dehydration and kidney problems. It can also cause gallbladder issues. It is important to consult a healthcare provider before taking Zepbound, especially if you have other medical conditions, take birth control pills, or are scheduled for surgery.
Zepbound is one of the most effective weight-loss medications available, and it stands out for its impressive weight loss results and positive impact on cardiovascular and metabolic health.
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Naltrexone-bupropion is a combination of an opioid receptor antagonist and an antidepressant
As of July 2025, tirzepatide (Zepbound) is the most effective FDA-approved prescription medication for weight loss. However, Naltrexone-bupropion, a combination of an opioid receptor antagonist and an antidepressant, is also a prescription diet pill.
Naltrexone-bupropion is a fixed-dose combination medication for the management of chronic obesity in adults. It is taken orally and combines naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. Both medications have individually shown some effectiveness in weight loss, and when combined, they have demonstrated synergistic effects. The medication targets the pleasure-reward areas of the brain, reducing cravings and appetite. It is usually taken twice a day, alongside a reduced-calorie diet and increased physical activity.
The safety and effectiveness of Naltrexone-bupropion in children under 18 have not been studied. It is important to note that this medication should not be taken with opioid medications or street drugs, as it can lead to overdose and death. Additionally, patients should inform their doctors if they have taken opioids in the past, as they may be more sensitive to the effects of opioids after treatment with Naltrexone-bupropion.
Naltrexone-bupropion is sold under various brand names, including Contrave, Mysimba, and Orexigen. It was approved for marketing in the United States in 2014, in the European Union in 2015, and in Canada under the Contrave brand name in 2018.
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Orlistat (Xenical) is a lipase inhibitor that reduces fat absorption in the gut
As of July 2025, tirzepatide (Zepbound) is the most effective FDA-approved prescription medication for weight loss. However, orlistat (Xenical) is also a prescription diet pill that has been approved by the US Food and Drug Administration (FDA) for the treatment of obesity.
The primary action of orlistat occurs in the gut, resulting in minimal systemic exposure to the medication. It is available in oral tablet formulations, with strengths of 60 mg (available over the counter) and 120 mg (prescription product). The recommended dosage is one 120 mg capsule taken orally three times daily during or within one hour after a fat-containing meal. It is important to note that orlistat should be combined with a nutritionally balanced, low-calorie diet with less than 30% of calories from fat.
Several trials lasting up to 2 years have shown that orlistat is more effective than diet alone for weight reduction and maintenance of lost weight. It also leads to improvements in total cholesterol, low-density lipoprotein, blood pressure, and fasting glucose and insulin concentrations. However, it is important to be cautious of potential gastrointestinal side effects, especially when taken with a high-fat diet. Additionally, it may decrease the absorption of fat-soluble vitamins, so it is recommended to take a daily multivitamin supplement during therapy.
Overall, orlistat (Xenical) is a prescription diet pill that effectively reduces fat absorption in the gut, aiding in weight loss and improving related health markers. It is generally safe when combined with a balanced diet and regular exercise, but it is always important to consult with a healthcare professional before starting any medication or weight loss program.
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Contrave is a combination medication of bupropion and naltrexone
Contrave is a prescription diet pill that combines two medications: bupropion and naltrexone. It is designed to help people lose weight or maintain weight loss. The medication works by affecting the pleasure-reward areas of the brain, decreasing cravings and appetite. It is intended to be used in conjunction with a reduced-calorie diet and exercise.
As a combination medication, Contrave harnesses the effects of both bupropion and naltrexone. Bupropion is an antidepressant that can also be used to treat depression. It is important to note that bupropion may increase the risk of suicidal thoughts or actions in a small number of children, teenagers, or young adults, especially when first starting the medication or when the dose is changed. Naltrexone, on the other hand, is an opioid receptor antagonist. When combined, these two drugs work synergistically to affect the brain's pleasure-reward areas, reducing cravings and appetite.
Contrave is typically administered orally as a tablet that must be swallowed whole. It can be taken with or without food, but it is important to avoid taking it with high-fat meals as this may increase the risk of seizures. Patients should follow the directions on their prescription label and take the medication at regular intervals. It is important not to cut, crush, or chew the tablets.
While Contrave can be an effective tool for weight loss and weight management, it is not suitable for everyone. It is important to discuss any changes in mood with a healthcare provider and be cautious about potential side effects. Some common side effects of Contrave include nausea, constipation, and headaches. Additionally, Contrave may cause hallucinations or psychotic-like behaviours in some individuals. It is crucial to inform your healthcare provider about any history of mental health problems before taking Contrave.
Contrave may also interact with other medications, so it is important to disclose all other medications, herbs, supplements, and lifestyle habits, such as smoking or alcohol consumption, to your healthcare provider. This medication may also affect blood sugar levels, so patients with diabetes should monitor their blood glucose levels and consult their healthcare provider for adjustments if needed. Overall, Contrave is a prescription diet pill that combines bupropion and naltrexone to help individuals lose weight, but it should be used under the guidance of a healthcare professional due to potential side effects and interactions.
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Qsymia (phentermine and topiramate) is a prescription medicine for adults and children
Qsymia is not suitable for those who are pregnant or planning to become pregnant, as it can cause birth defects. It is also contraindicated in individuals with glaucoma, thyroid problems (hyperthyroidism), or those taking monoamine oxidase inhibitors (MAOIs). Furthermore, Qsymia may cause serious side effects such as suicidal thoughts or actions, mood changes, trouble sleeping, concentration and memory issues, and visual problems. It is important to consult a healthcare professional before taking Qsymia to ensure it is safe and appropriate for individual needs.
Qsymia is typically taken once daily as a tablet or extended-release capsule. It is a controlled substance due to its potential for misuse or dependence. The medication should be stored at room temperature, between 68°F to 77°F (20°C to 25°C). It can be exposed to temperatures between 59°F to 86°F (15°C to 30°C) for short periods during transportation. Proper storage is crucial, and Qsymia should be kept in a cool, dry place in a tightly closed container.
While Qsymia has shown effectiveness in aiding weight loss, it is important to note that it is not a replacement for physical activity and healthy eating habits. Studies indicate that weight management medications, including Qsymia, are most effective when combined with a comprehensive lifestyle program that includes healthy dietary and behavioural changes, alongside increased physical activity. This holistic approach ensures that individuals not only lose weight but also maintain their weight loss over time.
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Frequently asked questions
Zepbound (Tirzepatide) is the latest prescription diet pill to be approved by the FDA in November 2023.
Zepbound is a dual GIP and GLP-1 receptor agonist that suppresses appetite, improves satiety, and supports metabolic health. It is also the most effective prescription diet pill on the market, with adults achieving up to 22.5% average body weight reduction at 72 weeks.
Zepbound is approved to treat obesity in adults with a BMI of 30 or greater. It is not recommended for those with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
