
Losing weight can be challenging, and while a nutritious diet and exercise are often recommended, they may not always yield results. In such cases, weight loss pills and medications can be beneficial. Several prescription-only pills are FDA-approved for weight loss, including Orlistat, Phentermine, Liraglutide, Bupropion-naltrexone, and Semaglutide. These medications act as appetite suppressants, boost metabolism, and prevent fat absorption. However, they should be used under medical supervision and in conjunction with a healthy diet and physical activity. Qsymia (phentermine/topiramate ER) is another popular option, with studies showing that it helped around 70% of adults lose at least 5% of their body weight after one year. Natural alternatives, such as fiber supplements, can also aid weight loss by prolonging feelings of fullness and reducing appetite. Ultimately, a holistic approach combining weight-loss medication with lifestyle changes is ideal for achieving sustainable results.
| Characteristics | Values |
|---|---|
| How it works | Reduces appetite, increases metabolism, or blocks fat absorption |
| Effectiveness | Studies show that semaglutide can help users lose up to 15% of their body weight. Qsymia helped about 70% of adults lose at least 5% of their body weight after 1 year. Close to 50% of participants lost at least 10% of their body weight. Orlistat helped up to 55% of adults lose 5% or more of their body weight after 1 year. Up to 25% lost at least 10% of their body weight. |
| Side effects | Headache, overstimulation, high blood pressure, insomnia, rapid or irregular heart rate, and tremor. Common adverse reactions to orlistat are oily discharge from the rectum, flatulence with discharge, increased defecation, and fecal incontinence. |
| Best used with | Healthy diet and exercise |
| FDA-approved | Yes |
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What You'll Learn

Prescription weight-loss pills
Several prescription weight-loss pills are available, and they work in different ways. For example, some medications may help you feel less hungry or full sooner. Others may make it harder for your body to absorb fat from the foods you eat.
Phentermine
Phentermine is a prescription medication frequently used to reduce hunger. It is usually prescribed for a short period and comes in the form of a tablet or capsule. It is available in both generic and brand name versions for people aged 17 and older. It is a controlled substance and has side effects like elevated heart rate and increased blood pressure.
Qsymia
Qsymia is a combination of phentermine and the seizure/migraine drug topiramate. It is a once-daily oral capsule for weight loss in people 12 years and older. It is a low-cost, highly effective pill, but it is not suitable for those with a history of substance misuse or dependency.
Contrave
Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formula. Naltrexone is approved to treat alcohol and opioid dependence, while bupropion is used to treat depression and seasonal affective disorder and help people stop smoking. It is an oral tablet that is taken twice a day, with a gradual increase in dosage over the first month.
Orlistat (Xenical, Alli)
Orlistat is a prescription medication that is taken three times a day, either with or within an hour of eating a meal that contains fat. It is the only drug of its kind approved in the U.S. and works by inhibiting an enzyme known as lipase, which prevents dietary fat from being absorbed in the intestines, decreasing caloric intake.
Liraglutide (Saxenda)
Liraglutide is an injection that suppresses appetite by mimicking a hormone that signals fullness, leading to reduced food intake and long-term weight loss. It is generally prescribed for overweight and obese patients and has potential side effects like nausea and diarrhea.
Semaglutide (Wegovy)
Semaglutide is currently the strongest prescription weight-loss medication approved by the FDA. It is especially effective for people with obesity or weight-related health conditions and can help users lose up to 15% of their body weight when combined with a healthy diet and lifestyle changes.
It is important to note that these medications are most effective when combined with lifestyle changes, such as a nutritious diet and routine exercise. Additionally, determining whether someone is a candidate for weight-loss medications involves considering their BMI, health history, and metabolic factors.
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Appetite suppressants
Over-the-counter appetite suppressants are also available, but none have been approved by the FDA. Some examples of over-the-counter appetite suppressants include Conjugated Linoleic Acid (CLA), which is a type of polyunsaturated fatty acid naturally found in foods like dairy and beef; bitter orange supplements, which are believed to increase the number of calories burned at rest; and Garcinia Cambogia pills, which contain hydroxycitric acid (HCA) and may reduce appetite by increasing serotonin levels in the brain.
It's important to note that appetite suppressants don't work on their own. They are most beneficial for weight loss when combined with a reduced-calorie eating plan and regular physical activity. Additionally, each appetite suppressant has side effects and risks, so it's important to consult with a healthcare provider to determine if they are right for you.
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Natural weight-loss pills
While there are prescription weight-loss pills available, such as Qsymia (phentermine/topiramate ER), Contrave (naltrexone/bupropion), and Orlistat (Xenical), some people may prefer to opt for natural alternatives. Natural weight-loss pills are typically supplements that contain herbal ingredients, vitamins, and minerals that can support weight loss in addition to a healthy diet and exercise routine. It's important to note that supplements are not regulated by the FDA in the same way that food and drugs are, so it's crucial to consult a healthcare provider before starting any new supplement.
One natural weight-loss supplement that has shown some promise is 7-keto-DHEA. In a couple of small studies, participants who took 7-keto-DHEA along with moderate exercise and a reduced-calorie diet lost significantly more weight than those who took a placebo. However, Natural Medicines states that there isn't enough reliable evidence to rate its effectiveness.
Chitosan is another natural supplement that has been touted for weight loss. It is derived from the hard outer layers of lobsters, crabs, and shrimp and is said to block the absorption of fats and cholesterol. However, the National Center for Complementary and Integrative Health states that chitosan has not been shown to be effective for weight loss, and Natural Medicines considers it "possibly ineffective."
Conjugated linoleic acid (CLA), found in some fatty acids, is another popular natural weight-loss supplement. Some research suggests that it may help curb body fat and suppress appetite, while other studies show no weight loss benefits. Natural Medicines considers CLA "possibly effective" for weight loss.
Chromium is a mineral that has been studied for its potential weight-loss benefits. However, a review of 24 studies found no significant weight loss benefits, and Natural Medicines rates chromium as "possibly ineffective" for weight loss. Higher doses of chromium can also cause kidney damage, so it should be avoided by anyone with kidney problems.
In addition to these specific supplements, some natural weight-loss pills may contain a combination of metabolism-boosting and appetite-suppressing ingredients, such as herbal extracts, vitamins B6, B12, D, and magnesium, and other nutrients. These can be beneficial when paired with regular exercise and a balanced diet to help accelerate progress toward weight loss goals.
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Side effects
While there is no consensus on the safest and most effective weight-loss pill, several options are available. Each pill has its own set of side effects, and it is important to consult a healthcare professional before taking any medication. Here are some of the most commonly mentioned side effects of top-rated diet pills:
Contrave (naltrexone/bupropion): Contrave is a prescription-only pill that combines two medications: naltrexone and bupropion. It works by reducing appetite and cravings for food. While it has shown promising results in initial studies, potential side effects include nausea, vomiting, headache, constipation, diarrhoea, abdominal pain, and indigestion.
Qsymia (phentermine/topiramate ER): Qsymia is a combination weight-loss pill that is available as a once-daily oral capsule for individuals aged 12 and above. It helps reduce appetite, and studies show that it aided a significant percentage of adults in losing at least 5-10% of their body weight. However, potential side effects include rapid or irregular heartbeat, mood changes such as depression or anxiety, cognitive changes like agitation or delirium, nausea, vomiting, diarrhoea, constipation, abdominal pain, and indigestion.
Orlistat (Xenical): Orlistat is a prescription weight-loss pill that comes in the form of an oral capsule taken three times a day with meals. It works by blocking the absorption of dietary fats. While it has been shown to help with weight loss, potential side effects include gastrointestinal issues such as oily discharge from the rectum, flatulence with discharge, increased defecation, and fecal incontinence.
Phentermine: Phentermine is available in different forms, including capsules and tablets. It can be combined with topiramate to reduce appetite and cravings. Side effects may include headache, overstimulation, high blood pressure, insomnia, rapid or irregular heart rate, and tremors. It is important to note that some individuals may have an allergic reaction to an ingredient called tartrazine found in Suprenza, a brand of phentermine.
Semaglutide (Wegovy): Semaglutide, also known by the brand name Wegovy, is administered as an injection. It is approved for use in adults and children aged 12 and above with obesity or excess weight and certain medical conditions. The dose is gradually increased over several weeks to minimise side effects, which may include gastrointestinal symptoms, headache, dizziness, and fatigue.
It is important to remember that the side effects of these medications can vary, and not all individuals will experience the same issues. Consulting a healthcare professional is crucial before starting any weight-loss medication to ensure it is safe and appropriate for your specific needs.
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Combining with lifestyle changes
Diet pills, also known as appetite suppressants, are a type of weight-loss medication for people with obesity or a body mass index (BMI) of over 30. They work by reducing your appetite or making you feel full faster, which can lead to a reduction in calorie intake and subsequent weight loss. Prescription appetite suppressants have been shown to help people achieve an average weight loss of 5% or more of their starting body weight.
Some of the top-rated diet pills available include:
- Qsymia (phentermine/topiramate ER): This is a combination weight-loss pill that is taken once daily and is suitable for individuals aged 12 and above. It helps reduce appetite and has been shown to help about 70% of adults lose at least 5% of their body weight after one year.
- Contrave (naltrexone/bupropion): This oral tablet combines two medications to reduce appetite and food cravings. In studies, over 40% of adults who took Contrave for a year lost at least 5% of their initial body weight.
- Phentermine (Adipex-P, ProFast, Dipex-P, Atti-Plex P, etc.): Phentermine is available in different forms and strengths, including capsules and tablets. It can also be combined with topiramate to further reduce appetite and cravings.
- Benzphetamine (Didrex, Regimex): This is a short-term appetite suppressant and controlled substance.
- Diethylpropion (Tenuate, Tenuate Dospan)
- Phendimetrazine (Prelu-2)
While diet pills can be effective, they should be combined with lifestyle changes for optimal results and long-term weight management. Here are some ways to combine diet pills with lifestyle changes:
Healthy Eating Habits
Adopting a nutritious diet is crucial when combining diet pills with lifestyle changes. Focus on increasing your protein intake, reducing refined carbohydrates, and avoiding unnecessary liquid calories. A reduced-calorie eating plan is often recommended alongside appetite suppressants to enhance their effectiveness. Additionally, consider using apps to log meals, track calories, and receive support from weight-loss coaches.
Regular Physical Activity
Engaging in regular physical activity is essential to complement the use of diet pills. Federal physical activity guidelines recommend at least 150 minutes per week of moderate-intensity aerobic activity and at least two days per week of muscle-strengthening activities. Combining diet pills with exercise can help with hunger management, cravings, and metabolic preservation.
Behavior Changes
In addition to diet and exercise, addressing behavioral triggers and habits can be beneficial. This may include improving sleep habits, managing stress, and making conscious choices to support your weight-loss journey.
Medical Supervision
Combining diet pills with lifestyle changes should be done under the supervision of a healthcare professional. They can help monitor your progress, adjust dosages, and address any side effects. Additionally, they can provide guidance on healthy eating and exercise habits that are tailored to your needs.
Alternative Weight-Loss Options
If diet pills and lifestyle changes are not sufficient, other weight-loss options can be explored. This may include injectable medications, weight-loss surgery, or other prescription medications. It is important to work closely with your healthcare provider to determine the best course of action for your specific situation.
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Frequently asked questions
There are several diet pills available on the market, and the best one for you will depend on your specific needs and preferences. Some popular options include Contrave (naltrexone/bupropion), Qsymia (phentermine/topiramate ER), phentermine (Adipex-P), liraglutide (Saxenda), and semaglutide (Wegovy).
Diet pills typically work by suppressing appetite, boosting metabolism, and reducing fat absorption. They are most effective when combined with lifestyle changes, such as a nutritious diet and regular exercise.
Yes, it is important to be aware of potential side effects before taking any diet pill. For example, phentermine may cause headaches, overstimulation, high blood pressure, insomnia, irregular heart rate, and tremors. Other side effects associated with weight loss medications include nausea, constipation, vomiting, dizziness, dry mouth, and diarrhea.
Diet pills are typically available through a prescription from your healthcare provider. It is important to consult with your doctor before taking any weight loss medication to ensure it is safe and suitable for you.











































