
There is a concern that very-low-calorie diets (VLCDs) can cause gallstones. VLCDs are defined as diets of fewer than 800 calories per day. However, a 1200-calorie diet is considered a low-calorie diet (LCD) and is not associated with a high rate of gallstone formation. In fact, a 1-year matched cohort study found that the risk of gallstones requiring hospital care was three times greater with VLCDs than with LCDs. Nevertheless, individuals who are obese or overweight may be more prone to developing gallstones, and rapid weight loss can increase this risk. Therefore, it is recommended to consult a doctor before starting a weight loss program to minimize the chances of developing gallstones.
| Characteristics | Values |
|---|---|
| Calorie intake | 1200 kcal/d (5025 Kj/d) |
| Fat intake | 20 g/d (15% of kcal) |
| Weight loss | 5.1 +/- 3.6 kg |
| Risk of gallstone formation | Not clinically significant |
| Effect on gallbladder health | May impact the salt and cholesterol contents of bile and the emptying of the gallbladder |
| Recommended alternative | Healthy, balanced diet with regular physical activity |
| Dairy intake | 2-3 portions/day of low-fat dairy products |
| Fruit and vegetable intake | At least 5 portions/day |
| Fibre intake | High-fibre carbohydrates |
| Fluid intake | At least 2 litres/day |
What You'll Learn

Losing weight quickly may increase the risk of gallstones
Losing weight can be a surefire way to reduce your risk of gallstones. However, losing weight too quickly may increase the risk of developing gallstones. Gallstones are rock-hard deposits that develop in the gallbladder, a small organ in the upper right abdomen, just below the liver. They can vary in size, from being barely visible to as large as a golf ball, and can be asymptomatic or extremely painful.
Gallstones form when bile, which aids in the digestion of fat, contains too much cholesterol or bilirubin and not enough bile acids or lecithin. When you don't eat for long periods or lose weight quickly, your liver releases extra cholesterol into the bile. This can cause an imbalance in the levels of cholesterol, lecithin, and bile acids, affecting gallbladder function. Rapid weight loss can also prevent the gallbladder from emptying properly, leading to bile stagnation and the formation of gallstones.
Weight-loss surgeries and very low-calorie diets can lead to rapid weight loss and a higher risk of gallstones. The faster the weight loss, the greater the chances of developing gallstones. Weight cycling, or losing and regaining weight repeatedly, can also increase the risk. Therefore, it is essential to avoid "crash diets" that promise quick weight loss. Instead, aim for slow and steady weight loss, which is generally considered safer and less likely to lead to gallstone problems.
If you are considering a very low-calorie diet or weight-loss surgery, consult your doctor to discuss ways to lower your chances of developing gallstones. Regular physical activity, healthy eating habits, and maintaining a healthy weight can all contribute to reducing the risk of gallstones.
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Very low-calorie diets can cause rapid weight loss
Very low-calorie diets (VLCDs) are defined as consuming fewer than 800 calories per day and are often used by people with obesity who want to lose weight quickly. VLCDs can cause rapid weight loss, but they are not recommended for everyone and may have side effects.
VLCDs are typically used for short-term weight loss and can be commercially-made formulas that replace all the food you usually eat. They are also sometimes used in combination with behavioural programs to improve long-term weight loss outcomes. While VLCDs can lead to rapid weight loss, they are generally only recommended for people with a BMI over 30 and should be done under proper medical supervision. For people who are overweight but not obese (BMI of 27-30), VLCDs should be reserved for those with weight-related medical problems and medical supervision is still necessary.
VLCDs may not be safe for everyone. They are not recommended for pregnant or breastfeeding women, children, teens, or older adults, except in specialized treatment programs. Side effects of VLCDs can include fatigue, constipation, nausea, and diarrhea, and they may also increase the risk of developing gallstones.
Gallstones are a common adverse effect of rapid weight loss and VLCDs. When the body experiences a calorie deficit, it breaks down fat for energy, and the liver secretes more cholesterol. This increase in cholesterol, when combined with bile, can form gallstones. Losing weight too quickly can also prevent the gallbladder from emptying properly, further increasing the risk of gallstones.
To lower the risk of gallstones and other health problems, it is recommended to lose weight at a slower pace and avoid "crash diets." Aiming for a weight loss of 5% to 10% of your starting weight over 6 months is a healthier approach. Combining a reduced-calorie diet with regular physical activity can also help lower the risk of gallstones and improve overall health.
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Weight cycling may lead to gallstones
Weight cycling, or losing and regaining weight repeatedly, may lead to gallstones. The more weight you lose and regain during a cycle, the greater your chances of developing gallstones. Weight cycling can be defined as intentional weight loss.
Gallstones are rock-hard deposits that develop in the gallbladder, a small organ in the upper right abdomen just below the liver. They can be asymptomatic or excruciatingly painful. The prevalence of gallstones is increasing worldwide, affecting about 20% of the population in Western countries and 5% in Eastern countries.
Weight cycling can increase the risk of gallstones in both men and women. A study using Korea's population-based health database found that out of 5,062,154 subjects, 31.6% maintained their weight, 27.5% experienced weight cycling over 10 years, and 16.1% experienced weight loss of 5-20%. The risk of gallstones associated with weight cycling was higher than those who maintained their weight. Another study found that weight cycling increased the risk of gallstones for both sexes, with a higher risk for males.
The mechanism by which weight cycling increases the risk of gallstones is not fully understood, but it is believed to be related to the intensity and frequency of weight fluctuations. Rapid weight loss can alter the balance of cholesterol, lecithin, and bile acids in the gallbladder, preventing it from emptying properly and leading to the formation of gallstones. Obesity can also increase the risk of gallstones due to excessive body weight and altered bile composition.
To lower the risk of developing gallstones, it is recommended to lose weight slowly and steadily, avoid crash diets, and increase physical activity. Maintaining a healthy weight and staying active can reduce the chances of gallstone formation.
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Obesity may increase the risk of gallstones
Obesity increases the risk of developing gallstones, with excess body weight being the main cause of gallstone disease (GD). Weight cycling, or losing and regaining weight repeatedly, may also lead to gallstones. The more weight lost and gained during a cycle, the greater the chances of developing gallstones.
A 2013 study showed that the risk of symptomatic gallstones increased by 7% with every one-point increase in Body-Mass-Index (BMI). Another study found that at least 25% of individuals with severe obesity (BMI > 40) have evidence of gallstone disease. Obese individuals may also have higher levels of cholesterol in their bile, which can cause gallstones. Obesity can also cause the gallbladder to not empty properly, leading to an increased risk of gallstones.
In addition to obesity, other factors that increase the risk of gallstones include physical inactivity, female sex, advanced age, pregnancy, family history of gallstone disease, and certain medications.
To lower the risk of developing gallstones, it is recommended to maintain a healthy weight through regular physical activity and a healthy diet. Losing weight too quickly may increase the risk of gallstones, so it is important to aim for slow and steady weight loss.
A 1200-calorie diet is considered a low-calorie diet (LCD) and has been associated with a lower risk of gallstones compared to very low-calorie diets (VLCDs, defined as <800 kcal per day). In a 1-year matched cohort study, adults in a commercial weight loss program who consumed 1200-1500 calories per day had a lower incidence of gallstones compared to those on a VLCD (500 kcal per day).
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Low-calorie diets may be safer than very low-calorie diets
A very-low-calorie diet (VLCD) is a type of diet with very or extremely low daily food energy consumption. VLCDs are defined as a diet of 800 kilocalories (3,300 kJ) per day or less. On the other hand, a low-calorie diet (LCD) typically means consuming around 1,200 to 1,500 calories per day to create a calorie deficit that can lead to weight loss.
VLCDs are more effective than low-calorie diets in terms of weight loss in the short term. They achieve approximately 4 kilograms (8.8 lb) more weight loss at 1 year and greater sustained weight loss after several years. However, VLCDs are not recommended for everyone. They are generally safe for people with a BMI greater than 30 when under proper medical supervision. For people who are overweight but not obese (BMI 27-30), VLCDs should be reserved for those with weight-related medical problems and are under medical supervision. They are also not recommended for pregnant or breastfeeding women, children, teens, and people over 50. People on VLCDs might experience minor side effects such as fatigue, constipation, nausea, and diarrhea.
The most common serious side effect of VLCDs is gallstones. Diets or surgeries that cause fast weight loss may be more likely to lead to gallstone problems than diets or surgeries that lead to slower weight loss. Losing weight very quickly may raise your chances of forming gallstones. When the body experiences a calorie deficit, it starts to break down fat for energy. The liver then secretes more cholesterol, and when combined with bile, can form gallstones.
LCDs, on the other hand, are broad-term diet plans that do not rely on specialty foods or dietary supplements. They simply call for real, whole foods available at any supermarket. They are more sustainable in the long term and have fewer side effects compared to VLCDs.
In conclusion, low-calorie diets may be safer than very low-calorie diets as they are more sustainable, have fewer side effects, and have a lower risk of gallstone formation.
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Frequently asked questions
A 1200-calorie diet is a low-calorie diet that restricts calorie intake to 1200 calories per day.
A 1200-calorie diet is considered a low-calorie diet, and low-calorie diets can cause sudden weight loss, which can trigger gallstones to form. However, very low-calorie diets (VLCDs) are typically defined as diets with fewer than 800 calories per day, and these are more likely to lead to gallstones.
Low-calorie diets typically consist of 1200-1500 calories per day and may include normal food in restricted portion sizes, whereas very low-calorie diets are usually defined as fewer than 800 calories per day and may involve liquid meals.
Very low-calorie diets can cause rapid weight loss, which can increase the risk of developing gallstones. They may also be associated with other adverse events and health problems.
To reduce the risk of developing gallstones, it is recommended to lose weight gradually by following a healthy, balanced diet and exercising regularly. Aim for a weight loss of 5 to 10% of your starting weight over six months and maintain a healthy weight. Consult with your doctor or healthcare professional before starting any new diet or exercise plan.

