Keto Dhea And Acne: Is There A Connection?

7-Keto-DHEA is a supplement derived from dehydroepiandrosterone (DHEA), a hormone produced by the adrenal glands. Unlike DHEA, 7-Keto-DHEA does not convert into hormones like testosterone and estrogen. While it is claimed to aid weight loss, boost metabolism, and enhance immune function, there is limited research on its effectiveness and potential side effects. This paragraph will explore the question: does 7-Keto-DHEA cause acne?

7-keto-DHEA is a metabolite of DHEA

Unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skin does not increase the level of these hormones in the blood. This is because, unlike DHEA, 7-keto-DHEA does not actively interact with sex hormones. Therefore, when taken as an oral supplement, it does not increase the amount of them in the blood.

DHEA is a precursor for the male and female sex hormones, including testosterone and estrogen. 7-keto-DHEA has a number of chemical names, including 7-ketodehydroepiandrosterone, 7-oxodehydroepiandrosterone, and 3β-Hydroxyandrost-5-ene-7,17-dione.

The benefits of 7-keto-DHEA supplementation are not definitively established. The health claims on potential weight loss benefits are not supported by solid evidence. The current evidence is mixed and limited by factors such as small sample sizes, short study durations, and a lack of diversity in the study populations. The safety profile of 7-keto-DHEA appears to be generally well-tolerated with a low side-effect profile, but changes in blood hormone parameters have been reported. Given these uncertainties, the potential benefits and safety of 7-keto-DHEA, particularly with long-term use, are not established.

The US Food and Drug Administration (FDA) has not added 7-keto-DHEA to the list of bulk drug substances due to a lack of clinical evidence regarding its safety and efficacy. The FDA has proposed that 7-Keto-DHEA be included among the substances banned from use in compounded drugs.

7-keto-DHEA does not convert to testosterone or estrogen

7-keto-DHEA is formed in the body from dehydroepiandrosterone (DHEA). Unlike DHEA, 7-keto-DHEA is not converted into hormones such as androgen and estrogen. This is because 7-keto-DHEA is not a precursor to testosterone or estrogen.

DHEA is a natural steroid produced in the adrenal glands, the gonads, and the brain. It is the most abundant circulating steroid in humans. 7-keto-DHEA is a byproduct of DHEA. However, unlike DHEA, 7-keto-DHEA is not converted into steroid hormones such as androgen and estrogen. This means that taking 7-keto-DHEA will not increase the level of these hormones in the blood.

The effects of 7-keto-DHEA may promote weight loss by speeding up the body's metabolism and converting more energy to heat instead of storing it as fat. People take 7-keto-DHEA for obesity, muscle strength, anxiety, depression, and many other conditions. However, there is no good scientific evidence to support these uses.

The safety profile of 7-keto-DHEA appears to be generally well-tolerated with a low side-effect profile. However, changes in blood hormone parameters have been reported. Given these uncertainties, the potential benefits and safety of 7-keto-DHEA, particularly with long-term use, are not established. The US Food and Drug Administration (FDA) has not added 7-keto-DHEA to the list of bulk drug substances due to a lack of clinical evidence regarding its safety and efficacy.

7-keto-DHEA may cause insomnia, anxiety and digestive issues

7-keto-DHEA is a natural steroid formed from dehydroepiandrosterone (DHEA) in the body. Unlike DHEA, 7-keto-DHEA is not converted into hormones like androgen and estrogen. While it is often taken to treat a variety of conditions, there is little scientific evidence to support its efficacy. These conditions include obesity, muscle strength, anxiety, and depression.

Although 7-keto-DHEA is possibly safe when used for up to 8 weeks and seems to be well-tolerated in the short term, it may cause insomnia, especially in women. This is a common side effect of DHEA supplementation, which 7-keto-DHEA is derived from.

In addition to insomnia, 7-keto-DHEA may also cause anxiety. While it is sometimes taken to treat anxiety, there is no good scientific evidence to support this use. Moreover, it is important to note that medications can affect different people in different ways. Even though 7-keto-DHEA may help some people manage their anxiety, it may make it worse for others or even trigger anxiety symptoms in those who don't usually experience them.

Lastly, 7-keto-DHEA may also cause digestive issues. As a supplement, it is important to follow the relevant directions on product labels and consult a healthcare professional before use, as natural products are not always safe and dosages can be important.

DHEA can lead to acne, oily skin and hair loss

DHEA (dehydroepiandrosterone) is a natural steroid produced in the adrenal glands, the gonads, and the brain. It is the most abundant circulating steroid in humans. As a precursor to other hormones, including testosterone and estrogen, DHEA plays a significant role in various biological functions. However, despite its potential benefits, DHEA can also lead to several side effects, particularly when taken in high doses.

One of the notable side effects of DHEA is its potential to cause acne. The increase in testosterone and estrogen levels triggered by DHEA can lead to hormonal imbalances, which can manifest as acne breakouts. While acne is more commonly associated with adolescence, DHEA-induced acne can occur at any age due to the artificial manipulation of hormone levels.

In addition to acne, DHEA can also cause oily skin. This side effect is often linked to the same mechanism that leads to acne. The excess production of natural skin oils, known as sebum, can not only clog pores and cause acne but also give the skin an oily appearance. This effect may be particularly noticeable in individuals with naturally oily skin or those who are prone to oiliness.

Furthermore, DHEA has been associated with hair loss. While the exact mechanism is not fully understood, it is believed that the hormonal imbalances caused by DHEA may disrupt the hair growth cycle, leading to hair loss or thinning hair. This side effect can occur in both men and women, although the pattern and extent of hair loss may differ between the sexes.

It is important to note that the side effects of DHEA are not universal and can vary from person to person. Some individuals may experience one or more of these side effects, while others may not experience any at all. Additionally, the severity of these side effects can differ based on factors such as dosage, frequency of use, age, and individual health characteristics.

Given the potential side effects of DHEA, it is crucial to consult a healthcare professional before considering its use. A skilled health care practitioner can provide guidance on whether DHEA is suitable for an individual's specific circumstances and help monitor for any adverse reactions or side effects.

7-keto-DHEA is likely safe with a low risk of serious side effects

7-keto-DHEA is a supplement that is derived from dehydroepiandrosterone (DHEA), a hormone produced by the adrenal glands. Unlike DHEA, 7-keto-DHEA is not converted into hormones like androgen and estrogen. Instead, it may increase metabolism and promote weight loss by converting more energy into heat. While there is limited research on its effectiveness, 7-keto-DHEA is considered likely safe and well-tolerated when taken orally for up to eight weeks.

Multiple studies have shown that 7-keto-DHEA is well-tolerated in humans, even at higher doses. One study found that men could tolerate doses of up to 200 mg per day for four weeks without serious side effects. Another study showed that 7-keto-DHEA was well-tolerated in both men and women at doses of 100-200 mg per day for eight weeks. However, some participants in these studies reported minor side effects such as heartburn, a metallic taste, and nausea.

The safety profile of 7-keto-DHEA is further supported by studies conducted on animals. In rats, 7-keto-DHEA was found to be non-toxic even at extremely high doses. Similarly, in monkeys, the supplement was well-tolerated at doses of up to 500 mg per kg of body weight.

Despite the relatively low risk of serious side effects, there are a few considerations to keep in mind. 7-keto-DHEA supplements have been known to trigger positive tests for performance-enhancing drugs, leading to their prohibition by the World Anti-Doping Association (WADA). Additionally, when applied to the skin as a gel, 7-keto-DHEA can affect sex hormones, cholesterol, and thyroid function in men. Therefore, it is essential to consult a doctor or pharmacist before using 7-keto-DHEA in gel form.

While the available research suggests that 7-keto-DHEA is likely safe for short-term use, more studies are needed to fully understand its long-term effects. It is always recommended to consult a healthcare professional before taking any new supplement, especially if you are pregnant, breastfeeding, or taking other medications.

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