
Apple seeds contain a chemical called amygalin, which releases cyanide when it comes into contact with human digestive enzymes. Cyanide is a deadly chemical that prevents cells in the body from using oxygen. However, apple seeds only release cyanide if they are crushed, and a large number of seeds would be required to cause harm. So, how many apple seeds would it actually take to kill a human?
| Characteristics | Values |
|---|---|
| Number of seeds in an average apple | 5-8 |
| Number of seeds that can be toxic | 83-500 |
| Number of seeds that can be fatal | 100-500 |
| Lethal dose of cyanide | 50-300 mg |
| Cyanide toxicity in humans | 0.5-3.5 mg/kg |
| Fatal oral dose of cyanide for a 154 lbs (70 kg) man | 1-2 mg/kg |
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What You'll Learn

Apple seeds contain cyanide
Apple seeds contain a chemical compound called amygdalin, which releases cyanide when it comes into contact with human digestive enzymes. Amygdalin is a cyanogenic glycoside composed of cyanide and sugar. When amygdalin is broken down by the body, it turns into hydrogen cyanide (HCN), which is highly toxic and can lead to death within minutes if consumed in large enough quantities.
However, it's important to note that apple seeds have a strong outer layer that is resistant to digestive juices. For cyanide to be released, the seeds need to be crushed or chewed. Even then, the human body can generally tolerate small amounts of cyanide, and it would take a large number of seeds (around 83 to 500 seeds, according to a 2018 analysis) to cause acute cyanide poisoning in an adult human. The exact amount required to cause harm depends on individual factors such as body weight and tolerance.
The variety of apple and the condition of the seeds also play a role. For example, a 2015 study found that Braeburn and Egremont Russet apples had lower amounts of amygdalin compared to other varieties. Additionally, the processing methods can affect the amount of cyanide present. Heating foods that contain cyanide, such as through pasteurization or cooking, causes the toxin to vaporize, reducing the potential harm.
While it is unlikely that consuming a small number of apple seeds will cause serious harm, it is still recommended to remove the seeds before consumption, especially when giving apples to young children or pets. This is because cyanide is a highly toxic chemical, and exposure to large amounts can lead to convulsions, slow heart rate, respiratory failure, and even death.
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How much cyanide is lethal?
Apple seeds contain amygalin, a substance that releases cyanide when it comes into contact with human digestive enzymes. However, apple seeds in small amounts do not contain enough cyanide to cause harm. For example, eating one or two apple seeds by accident, or drinking juice containing a few pulverized seeds, is unlikely to cause problems. But if a person or animal consumes a lot of apple seeds, it could make them sick.
The seeds of other fruits, including apricots and pears, also contain the same chemical. People can eat these fruits safely by avoiding the seeds, pits, or kernels.
The exact amount of cyanide that will make someone sick depends on their body weight and tolerance. A lethal dose of cyanide is around 50–300 milligrams (mg). A 2018 analysis of previous research states that a person would have to eat around 83–500 seeds to develop acute cyanide poisoning.
Cyanide is a broad-spectrum poison because the reaction it inhibits is essential to aerobic metabolism. Cyanide is a chemical known as one of the deadliest poisons. It has been used in chemical warfare and mass suicide. Many compounds that contain cyanide—called cyanoglycosides—are found in nature, often in fruit seeds.
The lethal oral doses of hydrogen cyanide and cyanide salts are estimated to be 50 mg and 100-200 mg, respectively. For skin exposures, the LD50 (the dose capable of killing 50% of the exposed group) is estimated to be 100 mg/kg. Vapor exposures in high concentrations (at or above the LCt50) typically can cause death in 6-8 minutes.
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Amygdalin in apple seeds
Apple seeds contain amygalin, a cyanogenic glycoside composed of cyanide and sugar. When chewed and digested, amygdalin releases cyanide into the bloodstream. Cyanide is highly toxic and can cause cyanide poisoning if consumed in large quantities. However, the amount of cyanide required to cause harm depends on individual factors such as body weight and tolerance.
Amygdalin is found in the seeds, kernels, and pits of many plants, including apples and other fruits in the Rosaceae family. The amount of amygdalin in apple seeds can vary depending on the variety of apple and the health of the plant. Some studies have quantified the amygdalin content in seeds from different apple varieties, with amounts ranging from 1 mg g(-1) to 4 mg g(-1).
While eating a few apple seeds is unlikely to cause harm, consuming large quantities of crushed or ground seeds could potentially lead to cyanide poisoning. A lethal dose of cyanide for an adult human is around 50–300 milligrams (mg). According to a 2018 analysis, a person would need to consume around 83–500 apple seeds to reach this toxic level. However, it is important to note that the exact amount of cyanide that can cause illness or death varies depending on individual factors.
The risk of cyanide poisoning from apple seeds can be minimized by spitting out the seeds instead of chewing and swallowing them. Additionally, removing seeds before juicing or processing apples can help reduce the potential for cyanide contamination in apple-based products. Pasteurization, a heat treatment that kills germs, is also effective in reducing amygdalin content in processed foods and juices.
While apple seeds contain amygdalin, the seeds themselves and the oil extracted from them have potential health benefits. Apple seeds are a rich source of amino acids, fatty acids, and polyphenolic compounds. Apple seed oil, a byproduct of juice processing, has been studied for its potential antioxidant, anticancer, antimicrobial, and skin-calming properties. However, rigorous and extensive research is still needed to promote the industrial use of apple seeds and their derivatives.
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How many seeds are in an apple?
Apple seeds contain a chemical called amygalin, which releases cyanide when it comes into contact with human digestive enzymes. Amygdalin is also found in the seeds of related plants, such as cherries and apricots. While small amounts of amygdalin can be detoxified by enzymes in the body, large amounts can be dangerous and even fatal. However, it is important to note that apple seeds have a strong outer layer that is resistant to digestive juices. As a result, accidentally swallowing a few whole seeds is unlikely to cause harm.
The number of seeds in an apple can vary, but on average, there are usually around four to five seeds per apple. This can differ depending on the health of the plant and the variety of apple. For example, a 2015 study in the United Kingdom found that Braeburn and Egremont Russet apples had the lowest amounts of amygdalin.
While eating a few whole apple seeds is generally safe, consuming large quantities of crushed or ground seeds could result in cyanide poisoning. A lethal dose of cyanide is around 50–300 milligrams, and a person would need to eat around 83–500 seeds to reach this amount. However, it is important to note that the exact quantity of cyanide that can cause illness depends on individual factors such as body weight and tolerance.
To avoid any potential health risks, it is recommended to remove apple seeds before juicing or giving apples to young children or pets. Additionally, if someone has swallowed a large number of seeds, it is advised to contact Poison Control or use the POISONCONTROL online tool.
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What happens if you eat apple seeds?
Apple seeds contain a chemical called amygalin, which is a cyanogenic glycoside composed of cyanide and sugar. When amygdalin comes into contact with human digestive enzymes, it releases cyanide into the bloodstream. Cyanide is a rapidly acting, potentially deadly chemical that prevents cells in the body from using oxygen. However, it is important to note that the outer layer of apple seeds is resistant to digestive juices, so swallowing whole seeds will not release cyanide. The seeds need to be crushed or chewed for the amygdalin to be released and potentially cause harm.
The good news is that eating one or two apple seeds by accident is unlikely to cause any problems. The human body can tolerate small amounts of cyanide, and the amount of amygdalin in a single seed is very low. Even if you accidentally swallow a few whole seeds, the chances of experiencing any negative effects are slim.
However, consuming a large number of crushed or chewed apple seeds could result in cyanide poisoning if the dose is high enough. A lethal dose of cyanide is around 50–300 milligrams, and a person would need to eat around 83–500 seeds to reach this amount. The exact quantity of cyanide that will make someone sick depends on their body weight and tolerance, as well as the variety of apple and condition of the seeds.
While it is unlikely that a person would eat enough apple seeds to reach a lethal dose, it is still recommended to remove the seeds before juicing or giving apples to young children or pets. If a person has swallowed a large number of seeds, it is important to seek medical advice or contact Poison Control for guidance.
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Frequently asked questions
Yes, apple seeds contain a sugar- and cyanide-based compound called amygalin. However, it takes quite a few of them to be crushed to kill a human.
According to a 2018 analysis, a person would have to eat around 83–500 seeds to develop acute cyanide poisoning. Another source estimates that it would take 250,000 seeds to be fatal.
Eating a few apple seeds is unlikely to cause symptoms. However, consuming large quantities of ground or crushed seeds could result in cyanide poisoning, which can lead to symptoms such as dizziness, nausea, convulsions, slow heart rate, and respiratory failure.

















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