
Fructose and glucose are both types of sugar. Fructose is found in fruits, vegetables, and honey, and is also a major ingredient in high-fructose corn syrup and table sugar. Recent studies have linked excessive fructose consumption to obesity, diabetes, and nonalcoholic fatty liver disease. On the other hand, glucose is essential for optimal blood sugar control and can be found in stone-ground and rolled oats, nuts, legumes, and certain fruits like raspberries, strawberries, blueberries, and blackberries. While it is important to limit the intake of added sugars and refined carbohydrates to manage blood sugar levels effectively, following a healthy dietary pattern that includes a variety of whole foods is crucial for maintaining overall health and well-being.
How to decrease fructose and increase glucose in diet
| Characteristics | Values |
|---|---|
| Fructose Intake | Avoid high-fructose corn syrup and agave syrup |
| Limit added sugars in diet | |
| Avoid soft drinks and fructose-sweetened beverages | |
| Reduce consumption of processed foods | |
| Glucose Intake | Consume glucose-sweetened beverages instead of fructose-sweetened ones |
| Increase consumption of whole fruits and vegetables | |
| Ensure adequate physical activity to balance energy intake | |
| Consider glucose supplements under medical supervision | |
| Metabolic Effects | Fructose produces a smaller postprandial rise in plasma glucose than glucose |
| Fructose needs to be converted into glucose by the liver before use by the body | |
| Excess fructose is metabolized into fat by the liver | |
| Health Effects | High fructose intake is linked to obesity, type 2 diabetes, heart disease, and increased risk of gout and kidney stones |
| Fructose impairs insulin signaling and contributes to insulin resistance | |
| Fructose may aggravate lipemia and increase triglyceride levels |
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What You'll Learn
- Avoid sugary drinks, fast food, salty snacks, and pizza
- Consume glucose-based sweeteners instead of high-fructose corn syrup or agave syrup
- Eat whole fruit, which is low in fructose and high in fibre
- Avoid high-fructose corn syrup, which is linked to serious health issues
- Consume glucose-sweetened beverages instead of fructose-sweetened ones

Avoid sugary drinks, fast food, salty snacks, and pizza
Sugary drinks are a leading source of added sugars in the diet, especially in the US. These include regular soda, sweetened fruit drinks, sports and energy drinks, and sweetened coffee and tea beverages. One way to decrease fructose and increase glucose in your diet is to limit your intake of these sugary drinks. Instead, opt for water, herbal tea, or unsweetened coffee.
Fast food is often nutritionally poor and high in calories, sugar, salt, saturated or trans fats, and processed preservatives and ingredients. It is also typically low in beneficial nutrients, fresh fruit and vegetables, and fiber. To improve your diet, it is best to avoid fast food. When eating out, choose grilled foods, such as chicken or fish, and opt for salads and plain rice.
Salty snacks, such as crisps and crackers, can be high in salt, as well as fat and sugar. Ready-made pasta sauces, particularly those that are cheese-based or contain meat, can also be very salty. To reduce your salt intake, choose lower-salt options, such as vegetable toppings on pizza, tomato-based pasta dishes, and sandwiches with chicken, egg, or vegetable fillings.
Pizza can be a salty and fatty food, especially when topped with pepperoni, bacon, or extra cheese. If you are going to eat pizza, choose vegetable or chicken toppings and a thin base. You could also try making your own pizza at home, controlling the amount of salt and sugar you add.
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Consume glucose-based sweeteners instead of high-fructose corn syrup or agave syrup
While glucose is the main energy source for your body's cells, fructose needs to be converted into glucose by the liver before it can be used by the body. Fructose is a type of simple sugar that constitutes 50% of table sugar (sucrose). Sucrose is the most common sweetener used in sweet desserts and baked goods. However, it is also found in various sugary sweeteners like high-fructose corn syrup and agave syrup.
High-fructose corn syrup has been linked to several serious health issues, including the obesity epidemic. Fructose stimulates insulin secretion less than glucose and glucose-containing carbohydrates. When people eat a diet that is high in calories and high in fructose, the liver gets overloaded and starts turning the fructose into fat. This is why many scientists believe that excess fructose consumption may be a key driver of many serious diseases, including obesity, type II diabetes, heart disease, and even cancer.
To decrease fructose and increase glucose in your diet, you can replace high-fructose corn syrup and agave syrup with glucose-based sweeteners. Novel sweeteners, sometimes called "plant-derived noncaloric sweeteners," are derived from natural sources. They provide many of the benefits of both artificial and natural sweeteners, such as fruit or honey. They are not a significant source of calories or sugar, so they don't lead to weight gain or blood sugar spikes. The FDA has approved several novel sweeteners, including stevia and monk fruit, as "generally regarded as safe."
It is important to note that sugar is not inherently bad, and our bodies do need sugar. The body processes the carbohydrates from food and turns much of it into glucose. The cells then pull the glucose from the bloodstream and use it for fuel and energy. Therefore, removing natural sources of sugar and other carbohydrates from your diet, such as fruits, dairy products, and grains, is not a healthy choice.
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Eat whole fruit, which is low in fructose and high in fibre
Eating whole fruit is an excellent way to decrease fructose and increase glucose in your diet. While fruit does contain fructose, it is not harmful in the same way as added fructose. Fructose is a simple sugar that occurs naturally in fruits and vegetables and gives them their sweet taste. It is also often used as a sweetener in packaged products like sodas, canned goods, and processed foods.
The fructose in fruit is not a cause for concern because it is a whole food with a low calorie density and lots of fibre. It is hard to overeat fruit, and you would have to consume very large amounts to reach harmful levels of fructose. In general, fruit is a minor source of fructose in the diet compared to added sugars.
When choosing fruit, opt for whole, local, and seasonal fruits, as they tend to be lower in fructose and higher in fibre. The skin of the fruit typically contains more fibre, so be sure to eat the fruit with the skin, after washing it thoroughly. Examples of low-fructose fruits include strawberries, oranges, blackberries, peaches, lemons, limes, avocados, and grapefruit.
It is important to note that modern fruit has been designed to have a higher sugar content, lower fibre content, thinner skin, and greater water content to make it juicier and more marketable. As a result, fruit juices tend to have a high sugar content, similar to that of soft drinks. Therefore, it is best to consume whole fruit and avoid fruit juices or dried fruit, which have a higher concentration of sugar and lower fibre content due to processing.
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Avoid high-fructose corn syrup, which is linked to serious health issues
High-fructose corn syrup is a sweetener that is commonly found in soft drinks, candies, and processed foods. It has been linked to a growing number of health issues, including:
Obesity: The consumption of high-fructose corn syrup has been associated with obesity. Studies have shown that consuming fructose-sweetened beverages increases visceral adiposity and lipids, leading to weight gain. The rise in the consumption of high-fructose corn syrup-containing beverages has paralleled the increase in obesity prevalence. Fructose stimulates insulin secretion less than glucose and glucose-containing carbohydrates, which can lead to lower circulating insulin and leptin, inhibiting appetite less and potentially leading to increased energy intake and weight gain.
Type 2 Diabetes: Several studies in humans have found a relationship between high fructose intake and type 2 diabetes. Fructose-sweetened beverages have been linked to an increased risk of developing type 2 diabetes, with human studies supporting this relationship. Fructose impairs insulin signaling in insulin-sensitive tissues, leading to insulin resistance and abnormal glucose tolerance.
Liver Dysfunction: High-fructose corn syrup has been associated with liver dysfunction and an increased risk of non-alcoholic fatty liver disease. The excessive consumption of fructose can lead to hepatic deposition of triglycerides and fatty liver without inflammation and oxidative stress.
Metabolic Disorders: The chronic ingestion of high-fructose corn syrup has been linked to metabolic disorders, including metabolic syndrome. Fructose consumption contributes to excessive dietary carbohydrate consumption, which can lead to dysregulation of energy homeostasis and lipid/carbohydrate metabolism.
Other Health Issues: High-fructose corn syrup has also been associated with increased risks of gout in men, kidney stones, and hyperglycaemia.
To avoid the potential health issues linked to high-fructose corn syrup, it is advisable to limit the consumption of soft drinks, candies, and processed foods that may contain this sweetener. Opting for natural sugars found in fruits and vegetables or alternative sweeteners can be a healthier choice.
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Consume glucose-sweetened beverages instead of fructose-sweetened ones
Consuming glucose-sweetened beverages instead of fructose-sweetened ones can be a good strategy to decrease fructose and increase glucose in your diet. This is because fructose-sweetened beverages have been linked to an increased risk of visceral adiposity and lipids, decreased insulin sensitivity, and impaired insulin signalling in insulin-sensitive tissues.
Fructose-sweetened beverages are associated with an increased risk of type 2 diabetes, insulin resistance, and hyperglycaemia. Fructose-sweetened beverages have also been linked to an increased risk of obesity, as they do not suppress appetite as effectively as glucose-containing beverages. This may lead to increased energy intake and weight gain.
On the other hand, glucose-sweetened beverages have been shown to increase fasting insulin in healthy humans, which can be beneficial for regulating blood sugar levels. Additionally, glucose is the main energy source for the body's cells and is more easily metabolized than fructose.
When choosing glucose-sweetened beverages, it is important to be mindful of the overall sugar content and to consume them in moderation. Sugar-sweetened beverages, including those sweetened with glucose, should be consumed in moderation as part of a balanced diet. Excessive consumption of sugary drinks can contribute to weight gain and increase the risk of health issues such as type 2 diabetes and metabolic syndrome.
It is worth noting that the natural fructose found in fruits and vegetables is not a significant cause for concern. The fructose in whole fruit is accompanied by fibre and antioxidants, making it a nutritious and healthy food choice. The concerns regarding fructose primarily apply to the Western diet, which includes excessive amounts of added sugars and calories.
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Frequently asked questions
Fructose is a common sugar found in fruits, vegetables, and honey. It is also a major ingredient in table sugar and high-fructose corn syrup.
While it is important to remember that fructose is not inherently unhealthy, it can be beneficial to reduce your intake of added sugars and refined carbohydrates. This means reducing your consumption of foods such as table sugar, corn syrup, molasses, cane sugar, corn sweetener, raw sugar, syrup, honey, and fruit juice concentrates.
Glucose is a type of sugar that is found in the blood and is the body's main source of energy.
Increasing glucose in the diet can be beneficial for those experiencing hypoglycemia, or low blood sugar. This can be done by consuming foods that are high in glucose, such as stone-ground and rolled oats, nuts, legumes, and certain fruits like raspberries, strawberries, blueberries, and blackberries. Avocados are also beneficial for blood sugar regulation, as they are rich in healthy fats, fiber, vitamins, and minerals.











































