
Weight loss medication is split into two categories: injections and tablets. The right medication depends on your medical history, BMI, and whether you prefer a tablet or injection. Weight loss medication is most effective when used in conjunction with a healthy diet and exercise plan. While diet and exercise are the foundation of weight management, some people cannot meet their weight loss goals with these methods alone. This has increased interest in prescription weight loss treatment as a supplementary solution.
| Characteristics | Values |
|---|---|
| Type | Pills/Tablets, Injections |
| Availability | Over-the-counter, Prescription |
| Effectiveness | Dependent on complementary lifestyle changes such as diet and physical activity |
| Side Effects | Temporary digestive changes, Changes in eating patterns, Increased energy, Headaches, Trouble sleeping |
| Examples | Orlistat, Xenical, Alli, Mounjaro, Wegovy, Liraglutide |
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What You'll Learn

Weight loss injections vs. weight loss tablets
Weight loss injections and tablets are medications that can help individuals reach their desired weight. The right weight loss medication depends on an individual's medical history, Body Mass Index (BMI), and personal preference. Weight loss injections and tablets are most effective when combined with a diet and exercise plan.
Weight loss injections are administered by injecting the medication into the upper arm, thigh, or stomach. Common weight loss injections include Wegovy, Ozempic, Mounjaro, Zepbound, and Nevolat. These injections are typically taken once a week or once a day, depending on the medication. Weight loss injections have been found to help individuals lose about 12% of their body mass, on average. However, they can be expensive, and insurance plans may not cover them for weight loss purposes. Additionally, injections can cause side effects such as gastrointestinal issues and, in rare cases, diabetes-related eye complications.
On the other hand, weight loss tablets are taken orally, usually once a day. Common weight loss tablets available in the UK include orlistat-based treatments such as Xenical, Alli, and Mysimba. While tablets offer a needle-free option, they must be taken in a specific way, such as on an empty stomach first thing in the morning. Similar to injections, weight loss tablets may also cause side effects, including gastrointestinal issues and changes in the female menstrual cycle.
Both weight loss injections and tablets have been found effective in facilitating weight loss. Research comparing the oral tablet and injectable forms of semaglutide, for example, has shown that both methods can lead to significant weight loss. However, more research is needed to accurately compare the two delivery methods, as they are relatively new medications.
It is important to consult with a healthcare professional before starting any weight loss medication, as they can have harmful interactions with other medications or health conditions. Additionally, weight loss medications should not be taken solely to improve physical appearance, as the side effects may outweigh the benefits in some cases.
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Side effects of diet pills
Diet pills, or weight-loss medications, can have several side effects, and these differ depending on the type of medication. It is important to note that these medications are typically intended for long-term use, and stopping them may result in rapid weight regain.
Stimulant-type weight loss medications, such as phentermine or diethylpropion, are associated with a risk of dependence and other side effects and are therefore only recommended for short-term use, typically up to 12 weeks. Orlistat (also known as alli or Xenical) can be used for longer-term weight loss and can be purchased without a prescription. However, it may cause side effects such as oily discharge from the rectum, flatulence with discharge, increased defecation, and fecal incontinence.
GLP-1 receptor agonists, such as liraglutide and semaglutide, are among the most effective medications for weight reduction. They work by reducing appetite and making you feel full faster. However, they often come with gastrointestinal side effects, including nausea, vomiting, acid reflux, bloating, stomach cramps, diarrhoea, and constipation. These symptoms are generally mild and temporary but can impact a patient's comfort and adherence to the medication.
Other potential side effects of weight loss medications include rapid or irregular heartbeat, mood changes such as depression or anxiety, cognitive changes like agitation or delirium, abdominal pain, indigestion, gallbladder disease, increased risk of fracture, and pancreatitis. In rare cases, tirzepatide, a medication initially approved for treating type 2 diabetes, may cause thyroid tumours or thyroid cancer.
To manage the side effects of weight loss medications, it is recommended to make dietary changes, such as limiting high-fat and greasy foods, sugary items, and spicy dishes. Eating smaller portions, prioritising adequate nutrition, and including high-fibre foods in the diet can also help alleviate side effects.
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Over-the-counter vs. prescription pills
Weight loss medication is available over the counter or by prescription in the UK. Over-the-counter medication is typically in the form of tablets, while prescription medication is available as either tablets or injections.
Over-the-counter pills
Alli is the only weight loss medication that can be purchased over the counter in the UK. It is available at a lower 60mg dose than prescription Orlistat and is sold in pharmacies following approval by a pharmacist. Alli works by blocking the absorption of around 25% of the fat in food. It should be taken within an hour of eating a meal that contains fat, up to three times a day.
Prescription pills
Prescription weight loss pills include Orlistat and Xenical. Orlistat is available on the NHS for treating obesity if patients meet the eligibility criteria. Xenical is the branded version of Orlistat. Both work by blocking the absorption of fat from meals.
Prescription injections
Prescription weight loss injections include Wegovy, Mounjaro, and Saxenda. Wegovy and Mounjaro are taken once a week, while Saxenda is taken daily. They work by mimicking hormones that target areas of the brain that regulate appetite, making you feel full sooner.
Prescription medication is typically recommended for adults with a BMI of 30 or above, or 27 and above with weight-related health conditions. It should be used in conjunction with a healthy, reduced-calorie diet and increased physical activity.
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Diet pills and weight loss surgery
Weight loss medication is split into two categories: injections and tablets. Weight loss injections currently licensed for use in the UK include Wegovy® and Mounjaro®. Tablets such as Orlistat can also be purchased over the counter. Weight loss medication should be combined with a low-calorie diet and regular exercise.
Weight loss treatment in the UK also includes the option of weight loss surgery, known as bariatric surgery. This type of surgery is only appropriate if you have tried to lose weight through dieting and exercise or if you are unable to use weight loss medication. Bariatric surgery can put Type 2 diabetes, sleep apnea, and cardiovascular disease into remission. People who undergo bariatric surgery can lose 77% of their excess weight within a year and maintain a 50% weight loss over five years.
Anti-obesity medications can also be used to help patients reach their pre-surgery weight goal more quickly than with diet and exercise alone. These medications can help patients lose up to 20% of their body weight and qualify for surgery. Injections may be more effective for long-term weight loss as they stop you from feeling hungry.
After weight loss surgery, patients will need to commit to long-term follow-up appointments and take lifelong vitamin supplements. They will also need to make large lifestyle changes to ensure the effects of the surgery are successful.
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Effectiveness of diet pills
The effectiveness of diet pills varies from person to person. Weight loss medication is most effective when combined with a healthy diet and exercise plan. Diet pills are designed to support people on their weight loss journey, providing an additional tool for those struggling to lose weight through diet and exercise alone.
There are several prescription weight loss treatments available in the UK, including Orlistat, Xenical, Mounjaro, Wegovy, and liraglutide (Saxenda). Orlistat is one of the most widely recognised and prescribed weight loss medications. It works by blocking the absorption of fat in the diet, so that the fat you eat is not digested and is instead excreted from the body. Orlistat is usually only recommended if patients have made a significant effort to lose weight through diet and exercise first. Alli is the brand name for over-the-counter Orlistat and is available at a lower dose.
Mounjaro is a self-injectable pen that helps reduce appetite and curb cravings. It has performed well in clinical trials, with patients reporting significant weight loss. Wegovy is another injection that can be used for weight loss and is most effective when combined with a healthy, reduced-calorie diet and increased physical activity.
It is important to remember that weight loss medication should only be taken if it has been prescribed to you by a doctor or pharmacist. Weight loss medication can have side effects, and it is important to consult a healthcare professional before starting any new treatment.
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Frequently asked questions
Orlistat is one of the most widely recognised and prescribed weight loss medications available in the UK. It is known for its effectiveness in helping users shed excess pounds. It works by inhibiting the enzyme lipase, which is necessary for the breakdown and absorption of fats in the diet. Alli is also available as an over-the-counter weight loss pill in the UK and is a lower-dose version of Orlistat.
The most common side effects of Orlistat are temporary digestive changes like loose stools or needing to go to the toilet more often. These effects are generally mild and can be minimised by a low-fat diet. Depending on the different types of weight loss tablets, some people may notice changes in their eating patterns or feel more energetic than usual.
Weight loss medication is split into two categories in the UK: weight loss injections and weight loss tablets. Weight loss injections include Mounjaro, Wegovy, and Saxenda. These medicines are taken as injections and help reduce your appetite by making you feel full and slowing down the time it takes for your stomach to empty.











































