
Weight loss pills are a popular option for those looking to lose weight, but with so many options available, it can be hard to know which one is right for you. Prescription weight loss pills are typically recommended for those with obesity or a high BMI, and work in different ways, such as reducing appetite or preventing the absorption of fat. Popular prescription weight loss pills include Wegovy, Qsymia, and Contrave, but there is no one pill that is considered to be the safest and most effective option overall. The best weight loss pill for you will depend on your individual needs and preferences, and it is important to speak to a healthcare professional before starting any new medication.
| Characteristics | Values |
|---|---|
| Effectiveness | Weight-loss pills work differently for different people. While some people may lose 5% of their body weight, others may lose 10%. |
| Timeline | There is no fixed timeline for diet pills to show results. However, if you do not achieve 5% weight loss in 12 weeks, the pill may not be effective for you. |
| Administration | Diet pills are administered orally. However, some are also available as injections. |
| Side effects | Side effects of weight-loss pills include abnormal sensations, dizziness, altered taste, insomnia, constipation, dry mouth, nausea, diarrhea, vomiting, headache, decreased appetite, dyspepsia, fatigue, abdominal pain, and renal insufficiency. |
| Precautions | Diet pills are not suitable for everyone. Consult a healthcare professional before taking any weight-loss medication, especially if you have substance use disorder or a family history of it. |
| Cost | The cost of diet pills varies. |
| Addiction | Some diet pills are controlled substances and can be addictive. |
| Diet and exercise | Diet pills work best in conjunction with a healthy diet and exercise. |
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What You'll Learn

Prescription appetite suppressants
There are various prescription appetite suppressants available, including:
- Liraglutide (Saxenda®): This is an under-the-skin (subcutaneous) injection medication.
- Semaglutide (Wegovy®): Also an injection, taken once a week and administered in the stomach area, upper leg, or upper arm.
- Naltrexone-bupropion (Contrave®): This is a pill.
- Phentermine-topiramate (Qsymia®): This is a pill. It is a once-daily oral capsule for individuals 12 years and older.
- Benzphetamine (Didrex®, Regimex®): This is approved for short-term use, typically up to 12 weeks.
- Diethylpropion (Tenuate®, Tenuate Dospan®): Also approved for short-term use.
- Phendimetrazine (Prelu-2®): A short-term appetite suppressant.
- Phentermine (Adipex-P®): This is also a short-term option.
It is important to note that prescription appetite suppressants are not a standalone solution for weight loss. Studies show that they are most beneficial when combined with a reduced-calorie eating plan and regular physical activity. Additionally, they may have side effects, and some short-term appetite suppressants have addiction potential, so it is crucial to consult with a healthcare provider before starting any medication.
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Weight-loss pills
Prescription weight-loss pills work in different ways. Some medications may help you feel less hungry or full sooner, while others may make it harder for your body to absorb fat from food. For example, Orlistat (Xenical) is a prescription pill that can be taken by adults three times a day with meals and works by reducing the amount of fat absorbed from food. It can also reduce the risk of regaining weight after losing it. In initial studies, Orlistat helped up to 55% of adults lose 5% or more of their body weight after one year. Alli is a similar over-the-counter option, although it is less potent than the prescription dose.
Other weight-loss pills combine an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain, thereby decreasing cravings and appetite. An example of this type of pill is Contrave (naltrexone/bupropion). In addition, Qsymia (phentermine/topiramate ER) is a once-daily oral capsule for weight loss in people 12 years and older that works by reducing your appetite. In initial studies, Qsymia helped about 70% of adults lose at least 5% of their body weight after one year.
It's important to note that weight-loss pills should be used in conjunction with a healthy eating plan and regular physical activity to be most effective. Additionally, the best weight-loss pill for you is one that helps you lose about 5% to 10% of your initial body weight with few or tolerable side effects. Different medications or combinations of medications will suit different people best, so it's important to consult with a healthcare professional before starting any weight-loss pill regimen.
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Side effects
It is important to note that there is no one-size-fits-all diet pill. The right pill for you will depend on your individual needs and goals. That being said, it is crucial to be aware of the potential side effects of any diet pill you are considering taking.
One of the most common side effects of diet pills is gastrointestinal issues. These can include nausea, vomiting, acid reflux, bloating, stomach cramps, diarrhoea, and constipation. These symptoms are generally mild and temporary but can be uncomfortable and may make it difficult for some individuals to stick to the treatment. To reduce these side effects, it is recommended to limit high-fat and greasy foods, as well as sugary and sweet foods and beverages. Eating smaller portions and choosing bland, easily digestible foods can also help.
Another potential side effect of diet pills is rectal issues. For example, Orlistat, a prescription weight-loss pill, can cause oily discharge from the rectum, flatulence with discharge, increased defecation, and fecal incontinence.
Some diet pills can also cause more serious side effects, such as stomach problems, kidney problems or failure, gallbladder issues, and pancreatitis. In rare cases, certain medications may even increase the risk of thyroid cancer. It is important to carefully consider the potential risks and benefits of taking diet pills and to consult with a healthcare professional before starting any new medication.
Additionally, it is worth noting that some diet pills can be habit-forming and may have the potential for abuse or misuse. It is crucial to follow the instructions provided by your healthcare provider and to be honest about any history of substance use disorder when considering prescription appetite suppressants.
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Lifestyle changes
While diet pills can be effective in helping you lose weight, they are not a cure-all solution and should be used in conjunction with lifestyle changes for sustainable results. Here are some lifestyle changes you can consider:
Healthy Eating Habits
Adopting a healthy eating plan is crucial. This includes making nutritious food choices, reducing your calorie intake, and opting for a low-fat diet. Focus on consuming a balanced diet with a variety of whole foods, including fruits, vegetables, lean proteins, and healthy fats. Additionally, pay attention to your portion sizes and practice mindful eating habits, such as chewing slowly and listening to your body's hunger and fullness cues.
Regular Physical Activity
Incorporating regular physical activity into your routine is essential. Aim for at least 30 minutes of daily exercise, such as walking, swimming, cycling, or joining a fitness class. Finding an activity you enjoy makes it easier to stick with it. Regular exercise helps burn calories, boosts metabolism, and improves overall health. It also promotes better sleep, which is crucial for weight management.
Addressing Eating Triggers
Understand and address your eating triggers. Identify any emotional or stress-related triggers that lead to unhealthy eating habits. For example, some people tend to overeat when stressed, anxious, or bored. Find healthier ways to cope with these emotions, such as practising meditation, deep breathing, or engaging in hobbies that provide a positive outlet for stress relief.
Improving Sleep Habits
Getting adequate and quality sleep is vital for weight management. Lack of sleep can disrupt hormones that control hunger and satiety, leading to increased appetite and cravings for high-calorie foods. Aim for 7-9 hours of sleep each night and establish a consistent sleep schedule. Practise good sleep hygiene by creating a relaxing bedtime routine, minimising screen time before bed, and ensuring your bedroom is cool, dark, and quiet.
Behaviour Changes
Consider joining a lifestyle program or working with a health coach to help you make sustainable behaviour changes. These programs can provide support, guidance, and accountability as you work on improving your eating habits and increasing your physical activity levels. They can also help address other weight gain factors, such as lack of sleep and emotional eating.
Remember, while diet pills can provide a short-term boost to your weight loss journey, lifestyle changes are crucial for long-term success and overall health. Always consult with your healthcare provider before starting any weight loss program or taking diet pills to ensure a safe and effective approach.
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Weight-loss injections
There are currently three FDA-approved weight-loss injections:
- Semaglutide (Wegovy® or Ozempic® when used for diabetes)
- Tirzepatide (Zepbound® or Mounjaro® when used for diabetes)
- Liraglutide (Saxenda® or Victoza® when used for diabetes)
Semaglutide and liraglutide work by targeting one gut hormone receptor, while tirzepatide is a dual agonist, targeting two receptors. These injections are designed to be used in conjunction with a reduced-calorie diet and increased physical activity to help manage weight and reduce the risk of major cardiovascular events in adults with obesity or overweight with associated medical problems.
While these injections have shown promising results, with some patients experiencing weight loss of upwards of 20%-22% of their excess body weight, they are not without drawbacks. The main challenges associated with their use are the cost and side effects, which include nausea, reflux, bloating, constipation, and diarrhea in about 10%-20% of patients.
It is important to consult with a healthcare professional before starting any weight-loss treatment, as they can assess individual needs and recommend the most suitable approach, which may include lifestyle changes, medication, or a combination of both.
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Frequently asked questions
Prescription appetite suppressants can help with weight loss for people with obesity. Some prescription diet pills include Contrave (naltrexone / bupropion), Qsymia (phentermine / topiramate ER), phentermine (Adipex-P), and Orlistat (Xenical).
The best weight-loss pill for you is one that helps you lose about 5% to 10% of your initial body weight with few or tolerable side effects. Different medications or combinations of medications will suit different people best. It's important to consult with your healthcare provider to determine the best option for you.
Yes, it's important to combine weight-loss medication with lifestyle changes such as a healthy eating plan and regular exercise to improve your chances of success. Appetite suppressants, for example, are most beneficial for weight loss when combined with a reduced-calorie eating plan and physical activity.











































