
Diet pills are prescription or over-the-counter medications designed to help users reduce or control their weight. They work by suppressing appetite, increasing metabolism, or preventing fat absorption. While they can be effective, they also carry a high risk of abuse and addiction, especially if used outside of the recommended dose. Diet pills are not suitable for everyone, and it is important to consult a doctor before taking them. They are typically recommended for individuals with a BMI of 30 or higher who have been unable to lose weight through diet and exercise alone. Even with diet pills, a healthy diet and regular exercise are necessary for effective weight loss.
| Characteristics | Values |
|---|---|
| Target Users | People with obesity (BMI ≥30) or a BMI of 27 with other related health problems |
| How they work | Affect how the body and brain experience appetite and hunger |
| Dosage | Varies from medication to medication |
| Results | People can lose 3% to 12% of their body weight |
| Side effects | Abnormal sensations, dizziness, altered taste, insomnia, constipation, dry mouth, nausea, diarrhoea, vomiting, headache, fatigue, abdominal pain, etc. |
| Effectiveness | Diet pills work best when combined with a healthy diet and exercise |
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What You'll Learn

Appetite suppressants
There are prescription and over-the-counter (OTC) appetite suppressants. Prescription appetite suppressants can be for long-term or short-term use. It is important to check with your healthcare provider before using OTC diet pills. Some OTC appetite suppressants may interact with medications or cause health problems. The Food and Drug Administration (FDA) has approved prescription appetite suppressants for long-term use, including Liraglutide (Saxenda®), an under-the-skin (subcutaneous) injection medication, and Semaglutide (Wegovy®), also an under-the-skin injection medication. Naltrexone-bupropion (Contrave®) and Phentermine-topiramate (Qsymia®) are also approved by the FDA and are taken as pills.
Other FDA-approved prescription appetite suppressants are for short-term use only, typically up to 12 weeks (three months). These include Benzphetamine (Didrex®, Regimex®), Diethylpropion (Tenuate®, Tenuate Dospan®), Phendimetrazine (Prelu-2®), and Phentermine (Dipex-P®, Atti-Plex P®, Pro-Fast® and others). These short-term appetite suppressants are controlled substances, which means they have addiction potential and can be dangerous if not used as intended. If you have a substance use disorder (SUD) or a family history of SUD, it is important to inform your healthcare provider before starting these medications.
While certain types of appetite suppressants can only be prescribed by a doctor, many are available over the counter. Some examples of OTC appetite suppressants include conjugated linoleic acid (CLA), which is a type of polyunsaturated fatty acid naturally found in foods like dairy and beef, bitter orange supplements, garcinia cambogia pills, and glucomannan, a type of soluble fibre derived from the edible roots of the konjac plant.
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Side effects
Diet pills, including prescription weight loss pills, and weight loss supplements often work by suppressing appetite or reducing the body's ability to absorb nutrients. However, they come with several side effects, some of which can be serious.
Gastrointestinal problems are the most common side effects of diet pills. During clinical trials, some participants experienced nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, bloating, and gas. To minimize these side effects, it is recommended to start with the lowest dose and stay on that dose for about four weeks before increasing it.
Some less common but more severe side effects include allergic reactions, pancreatitis, gallbladder problems, kidney damage, and serious bleeding. Rare but serious side effects of certain pills include seizures, liver damage, increased blood pressure or heart rate, and vision problems. There is also a boxed warning about the increased risk of suicidal thoughts and behaviors associated with bupropion, an ingredient in some diet pills. Furthermore, some people have complained about losing weight in the wrong places, such as their faces, which has resulted in a gaunt appearance.
The abuse of diet pills can also lead to tolerance, dependence, and withdrawal issues, especially in those with eating disorders, and may even serve as a gateway to developing eating disorders. It is important to consult a healthcare provider before taking any diet pills, as they can interact with medications or cause health problems.
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Weight loss results
Appetite suppressants are a type of weight-loss medication (sometimes called diet pills) that affect how your body and brain experience appetite and hunger. They can make you feel less hungry or full faster after eating less food. As a result, you may consume fewer calories and lose weight. Prescription appetite suppressants can help people achieve an average weight loss of 5% or more of their starting body weight. Phentermine-topiramate and GLP-1 receptor agonists (such as liraglutide and semaglutide) are among the most effective medications for reducing weight in people with obesity.
It is important to note that appetite suppressants do not work on their own. They are most beneficial for weight loss when combined with a reduced-calorie eating plan and regular physical activity. Some weight management medications are designed for short-term use, typically up to 12 weeks, while others are intended for long-term use. Most weight loss occurs within the first six months of starting the medication.
Naltrexone-bupropion is a weight-loss medication that combines an opioid receptor antagonist with an antidepressant to decrease cravings and appetite. Some patients may lose 5% to 10% of their body weight with this medication. Liraglutide, a daily injectable medication, can also help patients lose 5% to 10% of their body weight by reducing appetite and making them feel full quicker. Wegovy, Ozempic, Zepbound, and Mounjaro are brand names for semaglutide-based medications that are FDA-approved and used in combination with diet and exercise to treat obesity.
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FDA-approved pills
Diet pills, or appetite suppressants, are a type of weight-loss medication for people with obesity (a body mass index, or BMI, over 30). They affect how your body and brain experience appetite and hunger. Appetite suppressants can make you feel less hungry or make you feel full faster after eating less food. As a result, you may take in fewer calories and lose weight.
There are currently eight Food and Drug Administration (FDA)–approved weight-loss drugs on the market. These include:
- Orlistat (Xenical, Alli): This medication belongs to a class of medications called lipase inhibitors. Orlistat reduces the amount of fat absorbed in the gut after eating. When taking it, no more than 30% of your calories should come from fat.
- Phentermine-topiramate (Qsymia): This is an FDA-approved prescription appetite suppressant.
- Naltrexone-bupropion (Contrave): This is a combination medication that consists of an antidepressant and an opioid antagonist. The two work together to help you lose weight along with a low-calorie diet and appropriate exercise.
- Liraglutide (Saxenda, Victoza): This medication is approved for use in adolescents and young adults who do not achieve expected weight loss or who still have severe obesity after weight-loss surgery.
- Semaglutide (Wegovy): This medication was FDA-approved in 2021 for use in adults and children aged 12 and above with obesity. It is administered as an injection.
- Tirzepatide (Zepbound): This medication was approved for obesity in November 2023. It is administered as a subcutaneous injection.
It is important to note that medications do not replace physical activity or healthy eating habits as a way to lose weight. Studies show that weight management medications work best when combined with a lifestyle program, including healthy eating and increased physical activity.
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Prescription vs. over-the-counter
Diet pills, also known as appetite suppressants, are a type of weight-loss medication for people with obesity (a body mass index, or BMI, over 30). They work by blocking or increasing specific hormones, neurotransmitters, and/or peptides, which affect how the body and brain experience appetite and hunger. Appetite suppressants can make you feel less hungry or make you feel full faster after eating less food, resulting in reduced calorie intake and weight loss.
Prescription appetite suppressants are medications that require a doctor's prescription and are regulated by the U.S. Food and Drug Administration (FDA). They are typically recommended for individuals with a BMI of 30 or higher, or in some cases, a BMI greater than 27 with weight-related health issues such as type 2 diabetes, high blood pressure, or high cholesterol. These pills are generally considered safe if taken as prescribed and can help individuals achieve an average weight loss of 5% or more of their starting body weight. However, they may have side effects, especially short-term prescription appetite suppressants, which can include rapid or irregular heartbeat, mood changes, cognitive issues, nausea, and abdominal pain. It is important to consult a healthcare provider before taking prescription appetite suppressants to ensure they are suitable for your specific needs and medical history.
On the other hand, over-the-counter (OTC) weight-loss pills are available without a prescription and can be purchased at vitamin shops and drugstores. Currently, the only FDA-approved OTC weight-loss medicine is Alli (orlistat). Other OTC products are considered supplements and are not regulated by the FDA, which means their safety and effectiveness may not be adequately studied. While OTC weight-loss pills offer convenience and easier access, they may not undergo the same rigorous evaluation as prescription medications. It is important to note that some OTC weight-loss pills have been found to contain unlisted ingredients, including substances that have been banned by the FDA due to potential health risks. Therefore, it is crucial to carefully research and consult reliable sources and healthcare professionals before taking any OTC weight-loss pills.
Prescription appetite suppressants are often recommended as part of a comprehensive treatment plan that includes lifestyle modifications, such as a reduced-calorie diet and regular physical activity. They can be beneficial for individuals who have struggled to lose weight through diet and exercise alone. In contrast, OTC weight-loss pills may be preferred by those seeking a more convenient and immediate solution, but it is essential to approach these products with caution due to the potential lack of regulatory oversight and unknown risks.
When considering the use of diet pills, it is crucial to prioritize safety and effectiveness. Consulting a healthcare provider is essential to ensure that the chosen option aligns with your specific health needs, medical history, and potential interactions with other medications. Additionally, maintaining a healthy diet and engaging in regular physical activity are fundamental components of a holistic approach to weight loss and overall well-being.
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Frequently asked questions
Diet pills are a type of weight-loss medication for people with a high Body Mass Index (BMI). They are typically prescribed to people with a BMI of 27 or above who also have other related health problems, such as high cholesterol, heart disease, or Type 2 diabetes.
Diet pills, also known as appetite suppressants, affect how your body and brain experience appetite and hunger. They can make you feel less hungry or make you feel full faster after eating less food. As a result, you may consume fewer calories and lose weight.
Some examples of prescription diet pills include Benzphetamine (Didrex®, Regimex®), Diethylpropion (Tenuate®, Tenuate Dospan®), Phendimetrazine (Prelu-2®), Phentermine (Dipex-P®, Atti-Plex P®, Pro-Fast®), and Contrave. Alli is an example of an over-the-counter diet pill.
Side effects of taking diet pills can include abnormal sensations, dizziness, altered taste, insomnia, constipation, and dry mouth. Diet pills can also be addictive and may be dangerous if not used as intended or prescribed. It is important to consult with a healthcare professional before taking any weight-loss medication to ensure it is safe and appropriate for you.











































