7-Keto-DHEA is a steroid prohormone produced by the metabolism of the prohormone dehydroepiandrosterone (DHEA). Unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. It is often taken for obesity, muscle strength, anxiety, and depression, but there is no scientific evidence to support these uses. The US Food and Drug Administration (FDA) has not added 7-keto-DHEA to the list of bulk drug substances due to a lack of clinical evidence regarding its safety and efficacy.
Characteristics | Values |
---|---|
Is 7-keto DHEA FDA approved? | No |
Is 7-keto DHEA a controlled substance? | No |
Is 7-keto DHEA a prohibited anabolic agent in sport? | Yes |
Is 7-keto DHEA a steroid? | Yes |
Is 7-keto DHEA a hormone? | Yes |
Is 7-keto DHEA a prohormone? | Yes |
Is 7-keto DHEA a supplement? | Yes |
Is 7-keto DHEA a medication? | Yes |
Is 7-keto DHEA safe? | Possibly safe for up to 8 weeks, but there is limited evidence |
Is 7-keto DHEA effective? | There is limited evidence |
What You'll Learn
7-keto-DHEA is not an FDA-approved drug
The FDA's decision is supported by the fact that there is no good scientific evidence to support the use of 7-keto-DHEA for obesity, muscle strength, anxiety, depression, and other conditions. The benefits of 7-keto-DHEA supplementation are not definitively established, and the current evidence is mixed and limited by factors such as small sample sizes, short study durations, and a lack of diversity in the study populations.
Furthermore, 7-keto-DHEA is a powerful steroid hormone. Although it does not increase the level of steroid hormones in the blood, it can still cause side effects such as nausea, dizziness, or low blood pressure in some people. Long-term use of 7-keto-DHEA could potentially have more serious side effects, but there is insufficient data to determine the safety of long-term use.
In conclusion, 7-keto-DHEA is not an FDA-approved drug, and people who choose to ingest it should be concerned about unsubstantiated claims, questionable quality control, and safety issues associated with long-term use.
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It is a steroid prohormone derived from DHEA
7-Keto-DHEA, also known as 7-oxoprasterone, is a steroid prohormone derived from the metabolism of the prohormone dehydroepiandrosterone (DHEA). DHEA is a "parent hormone" produced by glands near the kidneys. Unlike DHEA, 7-keto-DHEA is not converted into steroid hormones like androgen and estrogen. This means that taking 7-keto-DHEA orally or applying it to the skin does not increase the level of steroid hormones in the blood.
The human body does not convert 7-keto-DHEA directly into testosterone or estrogen. This fact has led supplement suppliers to investigate it as a potentially more useful relative of the DHEA steroid when used as a supplement. However, the results of these investigations are inconclusive. The benefits of 7-keto-DHEA supplementation are not definitively established, particularly for weight loss. The current evidence is mixed and limited by factors such as small sample sizes, short study durations, and a lack of diversity in study populations.
The safety profile of 7-keto-DHEA appears to be generally well-tolerated with a low side-effect profile. However, changes in blood hormone parameters have been reported. Given these uncertainties, the potential benefits and safety of 7-keto-DHEA, especially with long-term use, are not established. The US Food and Drug Administration (FDA) has not added 7-keto-DHEA to the list of bulk drug substances due to a lack of clinical evidence regarding its safety and efficacy.
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It is not converted to testosterone or estrogen in the body
7-Keto-DHEA is a steroid prohormone produced by the metabolism of the prohormone dehydroepiandrosterone (DHEA). Unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. This means that taking 7-keto-DHEA orally or applying it to the skin does not increase the level of steroid hormones in the blood.
The human body does not convert 7-Keto-DHEA directly to testosterone or estrogen. This fact has led supplement suppliers to investigate its potential as a more useful relative of the DHEA steroid when used as a supplement. However, the results of these investigations are inconclusive.
The benefits of 7-keto-DHEA supplementation are not definitively established. The current evidence is mixed and limited by factors such as small sample sizes, short study durations, and a lack of diversity in the study populations. The safety profile of 7-keto-DHEA appears to be generally well-tolerated with a low side-effect profile, but changes in blood hormone parameters have been reported. Given these uncertainties, the potential benefits and safety of 7-keto-DHEA, particularly with long-term use, are not established.
The US Food and Drug Administration (FDA) has not added 7-keto-DHEA to the list of bulk drug substances due to a lack of clinical evidence regarding its safety and efficacy. The FDA has also proposed that 7-Keto-DHEA be included among substances banned from use in compounded drugs.
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It is marketed as a weight loss supplement
7-Keto-DHEA is a supplement that is marketed as a weight loss aid. It is produced naturally in the body from dehydroepiandrosterone (DHEA), a hormone that comes from the adrenal glands near the kidneys. Unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. This means that taking 7-keto-DHEA does not increase the level of steroid hormones in the blood.
It is often marketed as a weight loss supplement because it may increase metabolism and lead to weight loss. 7-keto-DHEA has thermogenic properties, meaning it can increase the body's temperature and prevent fat gain. It does this by increasing the levels of thermogenic enzymes that shuttle electrons in and out of the mitochondria. The energy released during this process is converted to heat, rather than stored as fat.
There have been a limited number of studies on the effects of 7-Keto-DHEA on metabolism. One study found that 7-Keto prevented the decline in metabolism associated with dieting and even increased it beyond baseline levels, burning an extra 96 calories per day. Another study found that participants taking 200 mg per day of 7-Keto lost 6.3 pounds, compared to a 2.1-pound weight loss in the placebo group. However, another study found no difference in basal metabolic rate between participants taking 7-Keto and those taking a placebo.
Despite its marketing as a weight loss supplement, there is limited evidence supporting the use of 7-keto-DHEA for weight loss. The US Food and Drug Administration has not added 7-keto-DHEA to the list of bulk drug substances due to a lack of clinical evidence regarding its safety and efficacy.
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It is banned by the World Anti-Doping Agency
7-keto-DHEA is banned by the World Anti-Doping Agency (WADA). WADA is responsible for the World Anti-Doping Code, which provides a framework for anti-doping policies, rules and regulations within sports organisations. The code has been implemented by over 660 sports organisations, including the International Olympic Committee.
WADA lists 7-keto-DHEA as a prohibited anabolic agent. This means that athletes who are subject to performance-enhancing drug tests should avoid taking 7-keto-DHEA supplements.
The detection of 7-keto-DHEA misuse in sports requires special attention, as it is naturally present in urine samples. The administration of 7-keto-DHEA to healthy volunteers has been studied to better describe the relationship between arimistane and 7-keto-DHEA. The study found that there is no formation of DHEA from 7-keto-DHEA.
The FDA has also proposed that 7-keto-DHEA be included among substances banned from use in compounded drugs.
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Frequently asked questions
No, 7-keto DHEA is not FDA approved. The US Food and Drug Administration (FDA) has not added 7-keto DHEA to the list of bulk drug substances due to a lack of clinical evidence regarding its safety and efficacy.
7-keto DHEA, also known as 7-oxo-DHEA, is a steroid prohormone produced by the metabolism of the prohormone dehydroepiandrosterone (DHEA). Unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen.
7-keto DHEA is generally well-tolerated with a low side-effect profile, but changes in blood hormone parameters have been reported. It may also cause mild side effects such as nausea, dizziness, or low blood pressure in some people.